Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source
HeliyonThe emergence of the digital economy has accelerated digital transformation, and digitalization has shown new potential and solutions to increasingly severe environmental challenges.
Wen Cheng +4 more
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The relationship between transformational leadership style, innovation capability, management accounting information systems, and performance in Vietnam’s manufacturing firms [PDF]
Problems and Perspectives in ManagementType of the article: Research Article AbstractThis study examines the interrelationships among transformational leadership style, innovation capability, management accounting information systems (MAIS) utilization, and firm performance within Vietnam’s ...
Thu Hien Nguyen +2 more
doaj +1 more source
Firms' transition towards green product service system innovators [PDF]
Within this paper we explore transition paths firms can take to become product service system (PSS) innovators. Applying the dynamic capability approach we study how three firms have developed PSS innovations in the mobility sector (Car2Go by Daimler AG,
Herstatt, Cornelius +2 more
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Building Strong Social Connections Increases Innovation Capability [PDF]
, 2012 For many years, we have been trying to understand why some work groups are more innovative than others even though they sit in the same departmental and corporate infrastructures as one another.
Center for Advanced Human Resource Studies, ILR School, Cornell University
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Knowledge management challenges in corporate venturing and technological capability building through radical innovations [PDF]
radical innovation, technological capability, corporate venturing, knowledge ...
Berends, J.J. +3 more
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FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
The impact of digital economy on regional technological innovation capability: An analysis based on China's provincial panel data. [PDF]
PLoS One, 2023 Tian Z, Li Y, Niu X, Liu M.
europepmc +1 more source
Managing Supplier Integration into Product Development: A Literature Review and Conceptual Model [PDF]
Industrial clusters, Regional agglomerations, Technological learning, Technological capability, Knowledge spillovers, Regional innovation ...
Echtelt, F.E.A. van, Wynstra, J.Y.F.
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