Results 81 to 90 of about 2,483,437 (255)
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Determinants of Innovation Capability in Small UK Firms: An Empirical Analysis [PDF]
The paper is an empirical investigation of key internal and external sources of innovation capability in small and medium firms (SME) in the UK. An experimental measure of innovation capability is designed, which captures not merely the occurrence of ...
Henny Romijn and Manuel Albaladejo
core
The impact of Dynamic Capability and Innovation Capability on Competitive Advantage [PDF]
کاوشهای مدیریت بازرگانی, 2018 Due to its highly changing nature and variety, competition nowadays requires capabilities that can provide competitive advantages for firms. The purpose of this research is to investigate the effect of dynamic capabilities and innovation capabilities on ...
Masoumeh Hoseinzadeh Shahri +1 more
doaj
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Technological intensity and innovation capability in industrial firms [PDF]
, 2018 Purpose – Over time, technological intensity has been used as a proxy for innovation capability of firms in an industrial sector. However, not only firms belonging to the stratum of high technological intensity are able to innovate. Therefore, this study
Tello-Gamarra, Jorge +3 more
core +2 more sources
Jurnal PerformaMicro, Small and Medium Enterprises (MSMEs) are the spearhead of the economy in Indonesia. This things is due to the contribution of MSMEs towards Indonesian economy quite large, that is, in the rate of 61 percent.
Dicky Wijaya, Hartono Subagio
doaj +1 more source
Enhancing innovation capability maturity through knowledge conversion
Acta Commercii, 2011 Purpose: This research was aimed at investigating organisational support by means of knowledge conversion processes toward maturity growth in innovation capability areas.
D. Esterhuizen +2 more
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
What Determines the Entrepreneurial Innovative Capability of Portuguese Industrial Firms? [PDF]
In the context of globalisation, innovation is considered as a key factor for enhancing the competitiveness of firms. Nowadays, it is widely accepted that Portuguese firms face an increasing competitive environment, which is characterised by ...
Silva, Maria José, Leitão, João
core
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source