Results 91 to 100 of about 2,483,437 (255)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

What Drives Innovation?: Inferences from an Industry-Wide Survey in Nigeria [PDF]

This chapter seeks to make some contributions to the literature on firm-level innovation in Africa by attempting to identify the significant factors that explain the capability of firms in Nigeria to innovate using the results of an industry-wide study ...
Egbetokun, A, Irefin, I, Olamade, O, Siyanbola, W, Adeniyi, A, Sanni, M   +5 more
core  

Exploring the Use of Innovation Performance Measurement to Build Innovation Capability in a Medical Device Company

, 2014
In order to increase their innovation capability, many organizations make the effort to actively change their R&D working practices. In parallel, measurement is an important issue with regard to managing innovation.
Nilsson, Susanne,, Susanne Nilsson, Sofia Ritzén, Ritzén, Sofia,   +3 more
core   +1 more source

The Interface of IT Capabilities and Disruptive Innovations. [PDF]

, 2017
The occurrence of disruptive innovations tends to challenge the fabric, structure and capability that define firms facing their threat. Prior research indicates that the capacity of a firm to restructure and reconfigure its resources to face/leverage such turbulent situations is dependent on how well it can orchestrate its capabilities.
openaire   +2 more sources

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Digital capability and green innovation: The perspective of green supply chain collaboration and top management's environmental awareness

Heliyon
The emergence of the digital economy has accelerated digital transformation, and digitalization has shown new potential and solutions to increasingly severe environmental challenges.
Wen Cheng, Qian Li, Qunqi Wu, Fei Ye, Yahong Jiang   +4 more
doaj   +1 more source

The relationship between transformational leadership style, innovation capability, management accounting information systems, and performance in Vietnam’s manufacturing firms [PDF]

Problems and Perspectives in Management
Type of the article: Research Article AbstractThis study examines the interrelationships among transformational leadership style, innovation capability, management accounting information systems (MAIS) utilization, and firm performance within Vietnam’s ...
Thu Hien Nguyen, Dao Tung Nguyen, Tuan Anh Nguyen   +2 more
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source