Results 91 to 100 of about 174,433 (312)

Exploring the Use of Innovation Performance Measurement to Build Innovation Capability in a Medical Device Company

, 2014
In order to increase their innovation capability, many organizations make the effort to actively change their R&D working practices. In parallel, measurement is an important issue with regard to managing innovation.
Nilsson, Susanne,, Susanne Nilsson, Sofia Ritzén, Ritzén, Sofia,   +3 more
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Firms’ digital capabilities and green collaborative innovation: The role of green relationship learning

Journal of Innovation & Knowledge
With the growth of the digital economy and environmental concerns, an increasing number of manufacturing firms are leveraging digitalization to advance their green innovation and sustainable development. Although previous studies have examined the impact
Xuemei Xie, Mengge Wang
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Determinants of Innovation Capability in Small UK Firms: An Empirical Analysis [PDF]

The paper is an empirical investigation of key internal and external sources of innovation capability in small and medium firms (SME) in the UK. An experimental measure of innovation capability is designed, which captures not merely the occurrence of ...
Henny Romijn and Manuel Albaladejo
core  

Technological intensity and innovation capability in industrial firms [PDF]

, 2018
Purpose – Over time, technological intensity has been used as a proxy for innovation capability of firms in an industrial sector. However, not only firms belonging to the stratum of high technological intensity are able to innovate. Therefore, this study
Tello-Gamarra, Jorge, Zawislak, Paulo Antonio, Tello Gamarra, Jorge Estuardo, Fracasso, Edi Madalena   +3 more
core   +1 more source

The impact of Dynamic Capability and Innovation Capability on Competitive Advantage [PDF]

کاوش‌های مدیریت بازرگانی, 2018
Due to its highly changing nature and variety, competition nowadays requires capabilities that can provide competitive advantages for firms. The purpose of this research is to investigate the effect of dynamic capabilities and innovation capabilities on ...
Masoumeh Hoseinzadeh Shahri, Sahebeh Shahini   +1 more
doaj  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

PENGARUH CUSTOMER ORIENTATION DAN COMPETITOR ORIENTATION TERHADAP KINERJA BISNIS MELALUI INNOVATION CAPABILITY

Jurnal Performa
Micro, Small and Medium Enterprises (MSMEs) are the spearhead of the economy in Indonesia. This things is due to the contribution of MSMEs towards Indonesian economy quite large, that is, in the rate of 61 percent.
Dicky Wijaya, Hartono Subagio
doaj   +1 more source

Enhancing innovation capability maturity through knowledge conversion

Acta Commercii, 2011
Purpose: This research was aimed at investigating organisational support by means of knowledge conversion processes toward maturity growth in innovation capability areas.
D. Esterhuizen, C. S.L. Schutte, A. S.A du Toit   +2 more
doaj   +1 more source