Results 161 to 170 of about 273,156 (307)

Molecular Design Learned from the Natural Product Porphyra-334: Molecular Generation via Chemical Variational Autoencoder versus Database Mining via Similarity Search, A Comparative Study

ACS Omega, 2022
Yuki Harada, Makoto Hatakeyama, Shuichi Maeda, Qi Gao, Kenichi Koizumi, Yuki Sakamoto, Yuuki Ono, Shinichiro Nakamura   +7 more
doaj   +1 more source

Identification of the IL-1β/miRNA-326 axis as a key regulator of ferroptosis in spinal cord injury. [PDF]

BMC Neurosci
Xu S, Jiang Y, Gui Y, Chen J, Pan Q, Jiang M, Xu J.   +6 more
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Reimagining early years services to address childhood inequities: learning from the Born in Bradford evaluation of a Better Start Bradford. [PDF]

BMJ Paediatr Open
Dickerson J, Ahern S, Mooney KE, Blower SL, Bhopal S, Bryant M, Bowyer-Crane C, Thornton G, Bennett K, Goldfeld S, Wright J, Pickett KE, McEachan RR.   +12 more
europepmc   +1 more source

Deep Brain Stimulation Induces Antidepressant Effects by Restoring High‐Fidelity Communication in the BNST‐NAc Circuit

Advanced Science, EarlyView.
This cross‐species study reveals that pathological hyperactivity of BNST neurons in depressive states disrupts inhibitory period and isolated spikes in the BNST‐NAc circuit. DBS achieves its antidepressant effects by precisely restoring network inhibitory periods and high‐fidelity signal transmission.
Xin Lv, Yu Cao, Yuhan Wang, Yunhao Wu, Yingying Zhang, Kuanghao Ye, Xian Qiu, Qingfang Sun, Liuguan Bian, Halimureti Paerhati, Valerie Voon, Shikun Zhan, Bomin Sun   +12 more
wiley   +1 more source

Identification and expression characteristics of porcine embryonic circRNAs during the peri-implantation. [PDF]

BMC Genomics
Gu S, Zhou C, Jiang L, Lin S, Wang Y, Li X, Ai J, Gu T, Li Z, Cai G, Wu Z, Hong L.   +11 more
europepmc   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Identification and Validation of DLD as a Cuproptosis-Associated Biomarker in Preeclampsia. [PDF]

FASEB J
Zheng S, Chen X, Tang W, Yang D, Han Q.
europepmc   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

Correction: Virus-like particle (VLP)-based indirect ELISA (iELISA) for the detection of beak and feather disease virus (BFDV) antibodies. [PDF]

Appl Microbiol Biotechnol
Dhar PK, Das T, Nath BK, Chowdhury P, Peters A, Forwood JK, Raidal SR, Das S.   +7 more
europepmc   +1 more source