Results 61 to 70 of about 2,341,120 (285)
المجلة الدولية للأداء الاقتصادي, 2023 This research sought to determine the strength and nature of relationship between innovation capability and the application of sustainable development pillars.
Rayane REZAK +2 more
doaj
INNOVATIVE WAY OF DEVELOPMENTAS A MECHANISM OF NATIONAL ECONOMY MODERNIZATION
RUDN Journal of Public Administration, 2017 In this article the authors discuss the importance of innovation in national development, stands out a chain and effect relationship between the development of innovative and natural improvement of quality of production.
Svetlana A Pervoykina, Denis N Putimtsev
doaj +1 more source
Specifics of management of enterprise innovation activities in the Czech republic - the decision-making mechanism [PDF]
, 2018 The majority of Czech managers are aware that the long-term competitiveness of the company depends primarily on the use of innovative technical solutions and investments in new technologies.
Franek, Jiří, Peterková, Jindra
core +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
ONTOLOGY INNOVATION MANAGEMENT
Вестник университета, 2019 In the article the ontology of innovation management, cognitive psychology of a manager are considered. There are expanded: special significance of language as a carrier of meaning and connection with practice; feedback philosophy of language, with ...
V. Ukolov, V. Kostryukov
doaj
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
AI-driven innovation within the ICT sector
Smart Cities and Regional Development JournalInnovation is pivotal in the competitive landscape of the Information and Communication Technology (ICT) sector, particularly in the context of rapidly evolving technological advancements.
Erika GRABOCKA, Ervisa NDOKA
doaj +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Administrative SciencesAs governments pursue digital transformation to improve service delivery and administrative efficiency, AI chatbots have emerged as a promising innovation in smart public administration.
Mansur Samadovich Omonov, Yonghan Ahn
doaj +1 more source