Results 61 to 70 of about 2,234,276 (312)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Physiotherapy-led, community-based airway clearance services for people with chronic lung conditions: a retrospective descriptive evaluation of an existing model of care

BMC Health Services Research
Objectives Airway clearance interventions are recommended for people with chronic lung conditions and mucus hypersecretion, but there are few published models of care or descriptions of airway clearance service provision.
Laura Cooper, Kylie Johnston, Marie Williams   +2 more
doaj   +1 more source

Hex-Bar Deadlift as a Post Activation Performance Enhancement Warm-up Strategy for Golf Club Head Speed

International Journal of Strength and Conditioning
Club head speed (CHS) is a key determinate of golf ball carry distance. Greater carry distance correlates with greater skill. The aim of the present study is to investigate the acute effects of using the hex - bar deadlift as a post activation ...
Amanda Ehrlich, Parker Dietzel, Merrick Lincoln, Doug Smith, Quincy Johnson, Gena Guerin   +5 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Innovation Project Performance Measurement: Selected Shortcomings

Littera Scripta, 2015
This paper presents an overview of studies that describe the emergence of innovation project performance measurement. It is dedicated to the issue of economic indicators and focuses on the metrics that can be employed to evaluate a single innovation ...
Ondřej Žižlavský
doaj  

Financial constraints, innovation performance, and sectoral disaggregation [PDF]

, 2012
How do the effects of financial constraints on innovation performance vary by sector and firm characteristics? This paper uses innovation survey data from eleven European countries to examine the heterogeneity of these effects.
Efthyvoulou, G., Vahter, P.
core  

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Study Of The Level Of Health And Food Culture Among Students Of The Institute Of Physical And Sports Education ( University Of Chlef )

مجلة العلوم و التكنولوجية للنشاطات البدنية و الرياضية
The objective of this study is to identify the level of food and health culture among students,A questionnaire was distributed to (281) students selected from three departments of the IEPS of the UHBC, namely the Department of Sports Training, Sports ...
Djaafri Asma, Guendez Ali
doaj   +1 more source

Innovation Indicators: for a critical reflection on their use in Low- and Middle-Income Countries (LMICs) [PDF]

, 2020
It has been widely recognized that innovation is an important driver of economic growth. Many Low- and Middle-Income Countries (LMICs) have adopted innovation indicators to monitor innovation performance and to evaluate the impact of innovation policies.
HOLLANDERS Hugo, IIZUKA Michiko, UNU-MERIT, 政策研究大学院大学 / National Graduate Institute for Policy Studies   +3 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source