Results 91 to 100 of about 1,855,001 (308)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Innovations in the Agricultural Sector [PDF]

, 2013
The aim of this paper is to show the impact and significance of innovation in agriculture. Its economic development takes place when innovation solutions based on knowledge and modern technologies are implemented and intensified.
Zrobek, Janusz
core  

The Innovation Innovation

, 2009
We seek explanation for how a species with our complex social systems could have arisen. We argue that an “innovation innovation” took place during hominin evolution that decoupled organizational change from a Darwinian evolutionary process and underlies the forms of social organization we find in human societies today.
D. Read, LANE, David Avra, S. van der Leeuw   +2 more
openaire   +3 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Ultra-Wideband RF-Photonics Technology for Microwave Spectrometry

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
We describe an RF-photonic system architecture to measure microwave spectrum over a wide bandwidth with high resolution. The approach relies on the up-conversion of the electronic signal to the optical domain using a high-speed electro-optic modulator ...
Janusz Murakowski, Amjed Hallak, Andrew Mercante, Mathew J. Zablocki, Timothy Creazzo, Shouyuan Shi, Kevin Shreve, Matthew Gallion, Connor Creavin, Charles E. Harrity, Michael Gehl, Mehmet Ogut, Shannon T. Brown, Sidharth Misra, Pekka Kangaslahti, Eric Kittlaus, Dennis W. Prather   +16 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Working methodologically on system innovations [PDF]

, 2011
Dutch agriculture is facing the challenge to develop into a sustainable sector. To achieve this goal, innovations are needed which force breaks with past trends and speed up the tempo of sustainable development. The System Innovation Programmes developed
Vogelezang, J.V.M., Wijnands, F.G.
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Validación del efecto de remediación y refinación catalítica de los catalizadores EcoEvol y su efecto en la mejora en la performance de motores a combustión interna

Ingeniería Industrial, 2016
Los motores a combustión interna son usados para distintas actividades económicas como el transporte, la generación de electricidad, minería, entre otras aplicaciones.
Darío Eder Lazo-Hoyos, Rodrigo Coquis Sánchez-Concha   +1 more
doaj