Results 91 to 100 of about 850,120 (308)

Crucial aspects for maintaining rAAV stability

Scientific Reports
The storage of rAAV vectors for gene therapy applications is critical for ensuring a constant product quality and defined amount of medication at the time of administration.
Johannes Lengler, Mia Gavrila, Janina Brandis, Kristina Palavra, Felix Dieringer, Sabine Unterthurner, Felix Fuchsberger, Barbara Kraus, Juan A. Hernandez Bort   +8 more
doaj   +1 more source

The Connecticut Innovations blog. 2013: Jul.

, 2014
Irregular; Began with Sept.

core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The Connecticut Innovations blog. 2009: Jun.

, 2009
Irregular; Began with Sept.

core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

The Connecticut Innovations blog. 2013: Jun.

, 2013
Irregular; Began with Sept.

core   +1 more source

An Innovative Dietary Ingredient Complex with Salidroside and L-Malic Acid Improves Markers of Perceived Stress and Anxiety in Adults: A Randomized Double-Blind Placebo-Controlled Clinical Study

Nutraceuticals
Adaptogens are substances touted for their ability to promote resilience to stress. With more individuals reporting a greater degree of perceived stress, renewed attention has been focused on novel adaptogen complexes for stress reduction. Salidroside is
Vignesh Nathan, Isha Shah, Devin Conley, Michael Lelah, Edward Dosz   +4 more
doaj   +1 more source

The Connecticut Innovations blog. 2010: Feb.

, 2010
Irregular; Began with Sept.

core  

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Functional Effectiveness of Hydrophobic Additives Based on PEGylated Hyperbranched Polymethylethoxysiloxane and Silicasol in Cement Systems

International Journal of Chemical Engineering
Concrete, as a building material, is strong and durable. However, under the influence of aggressive environmental factors, it can undergo corrosion and destruction.
N. Ye Bekturganova, I. V. Kolesnikova, N. Samenova, A. Suvorov, I. Kossenko, D. Yessentay, A. Belov, I. Rustemov, K. Borisov, A. Kalinina   +9 more
doaj   +1 more source