Results 111 to 120 of about 649,845 (314)

The Connecticut Innovations blog. 2010: Dec. [PDF]

, 2010
Irregular; Began with Sept.

core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The Connecticut Innovations blog. 2011: Nov. [PDF]

, 2011
Irregular; Began with Sept.

core  

Sex-related differences in fine motor skills and muscle strength control during short-term fasting

Scientific Reports
Despite the growing relevance of fasting-related effects on health promotion, studies related to its impact on motor behavior remain scarce. Thus, the aims of the present study were to determine the effects of short-term fasting on fine motor skills and ...
Rima Solianik, Nerijus Eimantas, Goda Daugė, Marius Brazaitis   +3 more
doaj   +1 more source

Hybrid Estimation of Inflow Multiphase Production Rates Using a Dynamic Wellbore Flow Model

Fluids
This paper considers the problem of estimating the quantitative parameters of a two-phase fluid flow in a well based on the dynamic physical flow model.
Anton Gryzlov, Eugene Magadeev, Andrey Kovalskii, Muhammad Arsalan   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Connecticut Innovations blog. 2011: Oct. [PDF]

, 2011
Irregular; Began with Sept.

core  

Functional Effectiveness of Hydrophobic Additives Based on PEGylated Hyperbranched Polymethylethoxysiloxane and Silicasol in Cement Systems

International Journal of Chemical Engineering
Concrete, as a building material, is strong and durable. However, under the influence of aggressive environmental factors, it can undergo corrosion and destruction.
N. Ye Bekturganova, I. V. Kolesnikova, N. Samenova, A. Suvorov, I. Kossenko, D. Yessentay, A. Belov, I. Rustemov, K. Borisov, A. Kalinina   +9 more
doaj   +1 more source

When Smoke Enters the City: Challenges for HVAC Filters in Resilient Buildings

Urban Science
Climate-driven increases in wildfire activity threaten urban air quality both through long-range smoke transport from rural fires and direct exposure as the wildland–urban interface expands.
Tanya Shirman, Hediyeh Zamani, Sissi Liu
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source