Results 101 to 110 of about 850,120 (308)

Low-dose radiotherapy enhances the efficacy of PD-L1 blockade and induces the abscopal effect

Journal for ImmunoTherapy of Cancer
Background Low-dose radiotherapy (RT) is a promising treatment likely to increase the efficacy of immunotherapy, including programmed cell death ligand 1 (PD-L1) blockade, in cancer therapy.
Pierre-Antoine Laurent, Eric Deutsch, Charlotte Robert, Antonin Levy, Michele Mondini, Marine Gerbé De Thoré, Winchygn Liu, Lydia Meziani, Céline Clémenson, Flavie Naulin, Liu Shi, Lisa Bouarroudj, Nathan Benzazon, Marine Aglave, Paul Bergeron, Lisa Sitterlé, Daphné Morel   +16 more
doaj   +1 more source

The Connecticut Innovations blog. 2010: Jul.

, 2010
Irregular; Began with Sept.

core  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Sex-related differences in fine motor skills and muscle strength control during short-term fasting

Scientific Reports
Despite the growing relevance of fasting-related effects on health promotion, studies related to its impact on motor behavior remain scarce. Thus, the aims of the present study were to determine the effects of short-term fasting on fine motor skills and ...
Rima Solianik, Nerijus Eimantas, Goda Daugė, Marius Brazaitis   +3 more
doaj   +1 more source

When Smoke Enters the City: Challenges for HVAC Filters in Resilient Buildings

Urban Science
Climate-driven increases in wildfire activity threaten urban air quality both through long-range smoke transport from rural fires and direct exposure as the wildland–urban interface expands.
Tanya Shirman, Hediyeh Zamani, Sissi Liu
doaj   +1 more source

The Connecticut Innovations blog. 2012: Mar.

, 2012
Irregular; Began with Sept.

core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Hybrid Estimation of Inflow Multiphase Production Rates Using a Dynamic Wellbore Flow Model

Fluids
This paper considers the problem of estimating the quantitative parameters of a two-phase fluid flow in a well based on the dynamic physical flow model.
Anton Gryzlov, Eugene Magadeev, Andrey Kovalskii, Muhammad Arsalan   +3 more
doaj   +1 more source

The Connecticut Innovations blog. 2012: Sep.

, 2012
Irregular; Began with Sept.

core