Results 111 to 120 of about 1,245,548 (303)

Imitational Models of the Innovation Development of a Country in Conditions of Internationalization [PDF]

The article reveals the characteristics and differences of the innovation process in the countries-leaders and countries-outsiders in innovations. Also the contents of the innovation process of the leaders in innovations are displayed here.
Alexandr Gribincea, Alexandr Iscenco, Natalia Percinschi   +2 more
core  

Second Roundtable Meeting: Innovations in Building Consumer Demand for Tobacco-Cessation Products and Services [PDF]

, 2007
Outlines February 2007 discussions at the National Tobacco Cessation Collaborative's Consumer Demand Roundtable on supporting the quitting process, building demand for products and services among employers and health plans, and design ...

core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Advancing Injection Molding: Innovations in Process, Materials and Applications

Journal of Manufacturing and Materials Processing
This Special Issue on Advances in Injection Molding: Process, Materials and Applications presents a curated collection of papers highlighting the dynamic evolution of this fundamental manufacturing technology [...]
Rossella Surace, Vincenzo Bellantone, Irene Fassi   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Consensus on innovations and future directions of community first responder schemes in United Kingdom: a national nominal group technique study

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Aim We aimed to achieve consensus among NHS and community stakeholders to identify and prioritise innovations in Community First Responder (CFR) schemes.
Gupteswar Patel, Vanessa Botan, Viet-Hai Phung, Ian Trueman, Mehrshad Parvin Hosseini, Murray D. Smith, Roderick Ørner, Julie Pattinson, Zahid Asghar, Elise Rowan, Robert Spaight, Craig Mortimer, Amanda Brewster, Pauline Mountain, Joshua Miller, Martina Brown, Aloysius Niroshan Siriwardena   +16 more
doaj   +1 more source

Healthcare as a cultural process: from traditions to innovations

Russian Studies in Culture and Society
Background. The article describes the transformation of understanding culture and medicine in modern society. There is a shift from static to dynamic models, where the patient's individual experience and values become central.
Elena A. Smirnova
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Decomposing Productivity Growth in the U.S. Computer Industry [PDF]

In this paper, we examine the sources of the productivity growth in the U.S. computer industry from 1978 to 1999. We estimate a joint production model of output quantity and quality that distinguishes two types of technological changes: process and ...
Chun, H., Nadiri, M.I.
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source