Results 91 to 100 of about 11,103,293 (250)
The Protection of Innovations [PDF]
This paper proposes a model where firms invest in secrecy to limit technological spillovers accruing to their competitors, in addition to investing in cost-reducing R&D.
Gamal Atallah
core
Perceptions of innovations: exploring and developing innovation classification [PDF]
, 2003 The capacity to innovate is commonly regarded as a key response mechanism, a critical organisational competence for success, even survival, for organisations operating in turbulent conditions.
Adams, Richard
core +2 more sources
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Scholar-based Innovations in Publishing [PDF]
, 2003 In recent years, a number of innovations have emerged that seek to provide sustainable alternatives to the predominant publishing paradigm. In this presentation, a variety of initiatives that exploit the inherent potential of the Web and other digital ...
McKiernan, Gerry
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Social Innovations in the Process of System Products Development [PDF]
Journal of Economics and Management, 2015 The article shows the essence of social innovation, its place and role in the development of innovative economy and innovative society. Social innovation is described as an active participation, entrepreneurship and creativity of different social groups ...
Anna Olejniczuk-Merta
doaj
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Russian Journal of Economics and LawObjective: to reveal the essence of educational organizations’ digitalization as the implementation of product- and processinnovations in their innovation activity from the managerial viewpoint, including (here) innovation statistics in the data economy.
A. I. Shinkevich +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source