Results 91 to 100 of about 1,245,548 (303)

GOVERNMENT BUDGET IN SYSTEM OF COST RECOVERY ON INNOVATIONS PRODUCTION: VARIATIVE APPROACH

Advanced Engineering Research, 2010
Instruments of financing innovative processes in the aspect of cost refunding on innovations development are considered. Limits and possibilities of the state participation in the system priming reproduction of innovative products in the Russian economy ...
Elena A. MIDLER
doaj  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Does patenting increase the private incentives to innovate? A microeconometric analysis [PDF]

This paper examines whether patenting increases the private incentives to innovate in manufacturing. To study this issue, we build a model in which the value of an innovation depends both on the type of innovation implemented (product, process) and on ...
DUGUET Emmanuel, LELARGE Claire
core  

GOVERNMENT BUDGET IN SYSTEM OF COST RECOVERY ON INNOVATIONS PRODUCTION: VARIATIVE APPROACH

Вестник Донского государственного технического университета, 2018
Instruments of financing innovative processes in the aspect of cost refunding on innovations development are considered. Limits and possibilities of the state participation in the system priming reproduction of innovative products in the Russian economy ...
Elena A. MIDLER
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Adoption of managerial innovations: effect of adoption rationales on the adoption process

, 2008
The aim of the research is to explore the complex phenomenon of the adoption of managerial innovations by organisations, with an attempt to identify relationships between various elements of this process.
Daniel, Elizabeth Mary, Dixon, Keith, Myers, Andrew   +2 more
core  

Transformative innovations igniting coffee supply chain process efficiency

Journal of Innovation and Entrepreneurship
Despite the geographical advantages of coffee plants and the high economic worth of Indonesian coffee goods, particularly in West Java Province, they have not resulted in significant production yields and economic benefits.
Maya Irjayanti, Anton Mulyono Azis, Susilawati, Andika Rizki Sobari   +3 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Disentangling Specific Subsets of Innovations : A Micro-Econometric Analysis of their Determinants [PDF]

Based on a unique firm-level data set from the German manufacturing sector, this paper disentangles environmental and non-environmental product and process innovations.
Andreas Ziegler
core  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source