Results 71 to 80 of about 1,245,548 (303)

Designing transition paths for the diffusion of sustainable system innovations. A new potential role for design in transition management? [PDF]

, 2008
Copyright @ 2008 Umberto AllemandiIt is a shared opinion that the transition towards sustainability will be a continuous and articulated learning process, which will require radical changes on multiple levels (social, cultural, institutional and ...
Ceschin, F, Kemp, R, Vezzoli, C
core  

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Deliberative Democracy in Practice: Handbooks on Commissioning, Facilitating, and Evaluating Deliberative Processes

Journal of Deliberative Democracy
Governments seeking to address declining trust, increasing polarisation, and greater complexity in government policy have increasingly turned to democratic innovations to engage citizens. For practitioners and academics alike, the term ‘deliberative wave’
Joanna Massie
doaj   +2 more sources

Do Firms R&D Collaborations with the Science System and Enterprise Group Partners Stimulate Their Product and Process Innovations?

Economies, 2019
There is a growing consensus that knowledge drives firms’ process and product innovations. An important source of these innovations is from firms networking with R&D partners, such as those in the science system and other industries in the ...
Samuel Amponsah Odei, Jan Stejskal
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

"Modelling In Innovation Process " [PDF]

Annales Universitatis Apulensis Series Oeconomica, 2008
SME competitive advantage is the resultant of actions aimed at full adaptationto the changing demands of external and internal environments. It may be assumed that theprocess of shaping the basic SME success factors is determined by corporate activity in thefields of research and development, production, distribution and customer service. Integrationof
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Enhancing Port Energy Autonomy Through Hybrid Renewables and Optimized Energy Storage Management

Energies
Hybrid renewable energy systems (HRESs) are being incorporated and evaluated within seaports to realize efficiencies, reduce dependence on grid electricity, and reduce operating costs.
Dimitrios Cholidis, Nikolaos Sifakis, Nikolaos Savvakis, George Tsinarakis, Avraam Kartalidis, George Arampatzis   +5 more
doaj   +1 more source