Results 71 to 80 of about 11,103,293 (250)

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Process and Product Innovations: Complements or Substitutes?

, 2010
This paper analyzes rms simultaneous choice in the intensity of process and product innovations, in market with vertical prod- uct di¤erentiation. Considering both monopoly and oligopoly models, we show that di¤erent shocks on the demand and cost ...
Tedeschi, Piero
core  

Control Dust on Gravel Roads with Soil Stabilization Innovations Polymers

, 2018
Now control dust on gravel roads with Soil Stabilization Innovations Polymers. Many government studies have proved that SSI polymers, when applied on gravel or dirt roads, produce more efficient results over the traditional methods.
soil stabilization innovations, soil stabilization innovations (5864486)   +1 more
core   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Enhancing Port Energy Autonomy Through Hybrid Renewables and Optimized Energy Storage Management

Energies
Hybrid renewable energy systems (HRESs) are being incorporated and evaluated within seaports to realize efficiencies, reduce dependence on grid electricity, and reduce operating costs.
Dimitrios Cholidis, Nikolaos Sifakis, Nikolaos Savvakis, George Tsinarakis, Avraam Kartalidis, George Arampatzis   +5 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Adoption of Product and Process Innovations in Differentiated [PDF]

The paper examines the effects of the degree of competition on the firms' decision to innovate in differentiated markets. We find that a low (high) degree of product differentiation (competition) weakly supports the introduction of new products.
Pia Weiss
core  

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

GOVERNMENT BUDGET IN SYSTEM OF COST RECOVERY ON INNOVATIONS PRODUCTION: VARIATIVE APPROACH

Advanced Engineering Research, 2010
Instruments of financing innovative processes in the aspect of cost refunding on innovations development are considered. Limits and possibilities of the state participation in the system priming reproduction of innovative products in the Russian economy ...
Elena A. MIDLER
doaj