Results 81 to 90 of about 242,551 (265)
FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Innovation as a community-spanning process: strategies to handle path dependency. [PDF]
In this paper, we further develop and apply the notions of path creation and path dependency during technological innovation processes. The process of technological innovation is portrayed as an activity of spanning boundaries between and across ...
Bouwen, René +2 more
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Smart materials. Technological innovations in architecture between product and process
, 2019 The revolutions that affected the construction process have traced a precise path also for the whole building sector, in which the innovation of materials and components become a priority. The construction of sustainable buildings was thus accompanied by
Fabio Conato, Valentina Frighi
core +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Commercializing Sustainable Innovations in the Market through Entrepreneurship [PDF]
, 2009 Organised by: Cranfield UniversityThe system innovations for sustainability require changes at multiple-domains (social, cultural, institutional and technological) and multiple-levels (micro-, meso-, and macro-levels) of the socio-technological system.
Keskin, D., Brezet, H., Diehl, J. C.
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FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
An assessment of five different theoretical frameworks to study the uptake of innovations
There are several theoretical frameworks one can draw upon to study the adoption process. Extension Theory, Bounded Rationality, Diffusion Theory, the Theory of Reasoned Action and Consumer Behaviour Theory were of particular interest to us. In assessing
Atkins, Kris, Botha, Neels
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