Results 101 to 110 of about 2,717,339 (281)

Investigation of the impact of diverse climate conditions on the cultivation suitability of Cinnamomum cassia using the MaxEnt model, HPLC and chemometric methods in China

Scientific Reports
Cinnamomum cassia Presl. is a subtropical plant that is used for food and medicine. Climate change has changed the suitable habitats of medicinal plants, which might have repercussions for the efficacy of herbal remedies.
Yanqun Li, Yang Yang, Dingze Gu, Yanrong Cheng, Xuejuan Lv, Yan Huang, Peng Ye, Xinxuan Zhang, Jing Zhang, Wanying Jian, Yujie Liu, Yingtong Guo, Mei Bai, Rongshao Huang, Hong Wu   +14 more
doaj   +1 more source

SHR-1806, a robust OX40 agonist to promote T cell-mediated antitumor immunity

Cancer Biology & Therapy
Anti-CTLA-4 and anti-PD-1/PD-L1 antibodies have significantly revolutionized cancer immunotherapy. However, the persistent challenge of low patient response rates necessitates novel approaches to overcome immune tolerance.
Jun Zhang, Lei Zhou, Xing Sun, Yuan Lin, Jimin Yuan, Changyong Yang, Cheng Liao   +6 more
doaj   +1 more source

Immune Checkpoint Blockade in Cancer Treatment: A Double-Edged Sword Cross-Targeting the Host as an “Innocent Bystander”

Toxins, 2014
Targeted immune checkpoint blockade augments anti-tumor immunity and induces durable responses in patients with melanoma and other solid tumors. It also induces specific “immune-related adverse events” (irAEs).
Lucia Gelao, Carmen Criscitiello, Angela Esposito, Aron Goldhirsch, Giuseppe Curigliano   +4 more
doaj   +1 more source

Further Education Funding Council : circular : 99/53 : ILT implementation plan : management and finance [PDF]

, 1999
"Information on the release of funds to assist in the development of college ILT infrastructure under the FEILT implementation plan.

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ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Culture industries in old industrialized regions: a successful strategy for innovative regional development? [PDF]

The proposed paper adresses the contribution of culture and culture industries to regional development in old industrialized regions. The need for innovative regional development strategies in these regions is high, because traditional stragies have not ...
Freundt, Andreas
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A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Exploring the Path of Innovative Development of Traditional Culture under Big Data. [PDF]

Comput Intell Neurosci, 2022
Li Z.
europepmc   +1 more source

Achieving Better Chronic Care at Lower Costs Across the Health Care Continuum for Older Americans [PDF]

, 2010
Outlines challenges to improving care for seniors, such as fragmentation of financing and care; promising models for infrastructure development, targeted care delivery improvements, and innovative payment methods; and resources in the 2010 reform ...

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