Results 91 to 100 of about 2,637,941 (347)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Anomaly Detection in Connected and Autonomous Vehicles: A Survey, Analysis, and Research Challenges

IEEE Access
In Intelligent Transportation Systems (ITS), ensuring road safety has paved the way for innovative advancements such as autonomous driving. These self-driving vehicles, with their variety of sensors, harness the potential to minimize human driving errors
S. Baccari, Mohamed Hadded, Hakim Ghazzai, Haifa Touati, Mourad Elhadef   +4 more
semanticscholar   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Feasibility of Innovative Tools and Methods to Improve Household Surveys in Complex Urban Settings: Multiple Methods Analysis of the Surveys for Urban Equity (SUE) Study in Kathmandu, Dhaka and Hanoi [PDF]

SSRN Electronic Journal, 2019
Background: The methods used in low- and middle-income countries (LMICs) household surveys have not changed in four decades; however, LMIC societies have changed substantially. This mismatch may result in unintentional exclusion of vulnerable and mobile urban populations.
Dana Thomson, Radheshyam Bhattarai, Sudeepa Khanal, Shraddha Manandhar, Rajeev Dhungel, Subash Gajurel, Joseph P Hicks, Duong Minh Duc, Junnatul Ferdoush, Tarana Ferdous, Nushrat Jahan Urmy, Riffat Ara Shawon, Khuong Quynh Long, Ak Narayan Poudel, Chris Cartwright, Hilary Wallace, Tim Ensor, Sushil Baral, Saidur Mashreky, Rumana Huque, Hoang Van Minh, Helen Elsey   +21 more
openaire   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

THE DEVELOPMENT OF INNOVATIVE ACTIVITY AS A CONDITION OF ECONOMIC GROWTH: TAJIKISTAN’S EXPERIENCE

Управленческие науки, 2015
This article considers the major problems of innovative activity ensuring the economic growth of Tajikistan Republic. It depicts the methods of the state’s innovative policy which refl the development of innovative activity.
M. Fayzulloev
doaj   +1 more source

Quantifying Changes in Creativity: Findings from an Engineering Course on the Design of Complex and Origami Structures [PDF]

, 2018
Engineering educators have increasingly sought strategies for integrating the arts into their curricula. The primary objective of this integration varies, but one common objective is to improve students’ creative thinking skills. In this paper, we sought
Anwar, Sohel, Fore, Grant, Hess, Justin L., Rao, Anusha Sathyanarayanan, Tovar, Andres, Wu, Jiangmei   +5 more
core  

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Analysis of the attitude of high school students to innovative types of motor activity in the system of school physical education

Слобожанський науково-спортивний вісник, 2019
Purpose: to study the subjective attitude of high school students to innovative types of motor activity in physical education lessons according to the questionnaire.
Tetiana Bala , Anhelina Petrova
doaj   +1 more source

Comprehensive analysis of clustering algorithms: exploring limitations and innovative solutions

PeerJ Computer Science
This survey rigorously explores contemporary clustering algorithms within the machine learning paradigm, focusing on five primary methodologies: centroid-based, hierarchical, density-based, distribution-based, and graph-based clustering. Through the lens
Aasim Ayaz Wani
semanticscholar   +1 more source