Results 121 to 130 of about 26,330 (311)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

When innovativeness in form matters: the joint impact of form innovativeness and expected innovativeness type on product evaluations over time [PDF]

, 2007
Past research in the area of product innovativeness has been dominated by studies conducted at the firm level. Furthermore, these studies principally lack a consumer perspective on the product innovativeness - product performance relationship.
Kroff, Michael William
core  

Extending consumer categorization based on innovativeness: Intentions and technology clusters in consumer electronics

, 2011
Consumer categorizations based on innovativeness were originally proposed by E.M. Rogers (2003) and remain of relevance for predicting purchasing behavior in high-tech domains such as consumer electronics.
Rijnsoever, F.J. van, Frank J. van Rijnsoever, Castaldi, C., Rijnsoever, van, F.J., Carolina Castaldi, van Rijnsoever, F.J.   +5 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Unlocking the power of endogenous factors for small business success. The role of knowledge management towards innovation

Journal of Innovation and Entrepreneurship
Small businesses play a crucial role in the economic development of both developed and developing countries. The purpose of this study is to gain a deeper understanding of the relationship between knowledge management and innovation, and how it can be ...
Tilahun Getnet Mirete, Samuel Godadaw Ayinaddis   +1 more
doaj   +1 more source

Antecedents of Firm Innovativeness: An Empirical Study of the Propensity and the Capability to Develop NewProducts

, 2006
New product development is a major field of research. Our paper represents a tentative attempt of appraising the diverse research streams, providing a systematic assessment of empirical studies, and organizing them into a framework covering aspects of ...
G. Calabretta, DURISIN, BORIS
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Determining the Innovativeness of Nurses Who Engage in Activities That Encourage Innovative Behaviors

Nursing Reports
Background: We sought to understand the innovativeness of nurses engaging in innovative behaviors and quantify the associated characteristics that make nurses more able to innovate in practice.
Marion Leary, George Demiris, J. Margo Brooks Carthon, Pamela Z. Cacchione, Subhash Aryal, Jose A. Bauermeister   +5 more
doaj   +1 more source

Innovativeness and Innovation: Implications for the Renewable Materials Supply Chain

innovativeness, innovation, supply chain management, triple bottom line, corporate social responsibility, Agribusiness, Agricultural Finance, Demand and Price Analysis, Financial Economics, Q10, Q27, Q42, Q47,
Johnson, Aaron J., Gray, Allan W., Detre, Joshua D.   +2 more
core