Results 101 to 110 of about 35,652 (254)
Unravelling Firm Innovativeness: Insights From An Empirical Investigation
, 2006 Although innovation is a major field of research, contributions on the concept of firm innovativeness are still limited. Specifically, there is no accordance on cultural and behavioural factors stimulating the propensity to innovate and enabling the ...
G. Calabretta, DURISIN, BORIS
core
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
When innovativeness in form matters: the joint impact of form innovativeness and expected innovativeness type on product evaluations over time [PDF]
, 2007 Past research in the area of product innovativeness has been dominated by studies conducted at the firm level. Furthermore, these studies principally lack a consumer perspective on the product innovativeness - product performance relationship.
Kroff, Michael William
core +2 more sources
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
TECHNOLOGICAL OPINION LEADERSHIP: PERAN DARI PERSONAL INNOVATIVENESS, GADGET LOVE, DAN TECHNOLOGICAL INNOVATIVENESS, DI SURAKARTA [PDF]
, 2017 ABSTRAK TECHNOLOGICAL OPINION LEADERSHIP: PERAN DARI PERSONAL INNOVATIVENESS, GADGET LOVE, DAN TECHNOLOGICAL INNOVATIVENESS, DI SURAKARTA KHARISMA NUR AZIZAH F0213058 Penelitian ini bertujuan untuk (1) menganalisis pengaruh antara personal innovativeness
AZIZAH, KHARISMA NUR
core
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Nursing ReportsBackground: We sought to understand the innovativeness of nurses engaging in innovative behaviors and quantify the associated characteristics that make nurses more able to innovate in practice.
Marion Leary +5 more
doaj +1 more source