Results 91 to 100 of about 35,652 (254)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
The impact of structural capital on the firm Innovativeness, the Galician Northern Portugal automotive industries reality [PDF]
The intellectual capital is increasingly considered a major issue on the management and organization research and a source of competitive advantage.
Pedro Figueroa +2 more
core
Innovativeness of nurse leaders
, 2011 The purpose of the present study was to describe the innovativeness and the rate of adoption of change among chief nursing officers (CNOs) of acute care hospitals, and explore the difference in the innovativeness of CNOs of Magnet hospitals vs.
Clement-O'Brien, Karen +7 more
core +1 more source
, 2014 Organizational culture and organizational innovativeness are viewed as important factors for improving the organizational effectiveness in institutions of higher education.
Lope Pihie, Zaidatol Akmaliah +3 more
core +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Indonesian Interdisciplinary Journal of Sharia EconomicsThe highly competitive landscape among food and beverage entrepreneurs in Indonesia compels brands to compete aggressively to attract and retain customers.
Qorina Firkiana +2 more
doaj
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Locational Conditions, Cooperation, and Innovativeness: Evidence from Research and Company Spin-offs [PDF]
This paper has two goals. First, it analyzes the extent to which the innovativeness of spin-offs, either born from a research facility or from another company, is influenced by locational conditions.
Anna Lejpras, Andreas Stephan
core
Effects of strategic leadership, organizational innovativeness and information technology capability on effective strategy implementation [PDF]
, 2016 The paper examined the role of strategic leadership, organizational innovativeness, information technology capability on strategy implementation in tertiary institutions situated at Kaduna state, Nigeria.
Palladan, Ahmad Aliyu +2 more
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source