Results 131 to 140 of about 260,266 (297)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

The Pharmaceutical Innovativeness Index: Supporting Value-Based Economic Regulation of Innovative Medicines. [PDF]

J Mark Access Health Policy
Gargano LP, Borin MC, Prata WM, Alvares-Teodoro J, Acurcio FA, Iunes RF, Guerra AA.   +6 more
europepmc   +1 more source

3.2. An innovative cell therapy strategy for ex vivo corneal endothelium regeneration [PDF]

Marina Bertolin, Alessandro Ruzza, Diego Ponzin, Moreno Piaia, Mattia Baruzzo, Stefano Ferrari   +5 more
openalex   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Innovation

Journal of the American College of Cardiology, 2013
openaire   +2 more sources

Virtual Reality and Three‐Dimensional Printing of Craniopharyngioma: A Case Report Proposing an Innovative Model of Pediatric Endocrine Care to Enhance Patient Engagement [PDF]

Valeria Calcaterra, Maurizio Vertemati, Francesco Rizzetto, Laura Grazia Valentini, Andrea Saladino, Cassandra Gazzola, Sara Zanelli, Francesca Colombo, Arianna Barbotti, Francesco Cavaliere, Tommaso Santaniello, Paolo Milani, Gianvincenzo Zuccotti   +12 more
openalex   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Individual innovativeness levels and levels of medical artificial intelligence readiness among nursing students: a cross-sectional and correlational study. [PDF]

BMC Med Educ
Kazanç Ş, Kavak HK, Karagözoğlu Ş.
europepmc   +1 more source