Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation
Molecular Oncology, EarlyView.Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza +5 more
wiley +1 more source
Effects of elevated [CO2 ] on maize defence against mycotoxigenic Fusarium verticillioides. [PDF]
, 2014 Maize is by quantity the most important C4 cereal crop; however, future climate changes are expected to increase maize susceptibility to mycotoxigenic fungal pathogens and reduce productivity. While rising atmospheric [CO2 ] is a driving force behind the
Alborn, Hans T +11 more
core +2 more sources
Perspectives of Microbial Inoculation for Sustainable Development and Environmental Management
Frontiers in Microbiology, 2018 How to sustainably feed a growing global population is a question still without an answer. Particularly farmers, to increase production, tend to apply more fertilizers and pesticides, a trend especially predominant in developing countries.
M. Ahmad +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun +5 more
wiley +1 more source
Experimental pneumonia induced by a Bordetella parapertussis-like organism in the ovine and murine lung : a thesis presented in partial fulfillment (70%) of the requirements for the degree of Master of Philosophy in Veterinary Pathology at Massey University [PDF]
, 1987 Thirty-four specific pathogen-free (SPF) Swiss mice were intranasally inoculated with a suspension containing about 3 x 10 7 colony-forming units (CFU)/ml of a B. parapertussis-like organism isolated from pneumonic ovine lung.
Chen, Wangxue
core
Molecular Oncology, EarlyView.We investigated whether hypomethylating agents (HMAs) used in myeloid malignancies induce somatic retrotransposition. Our findings indicate that HMA treatment increases L1‐encoded protein expression but does not lead to detectable de novo retrotransposition events in either patient samples or cell lines.
Šárka Pavlová +14 more
wiley +1 more source
The use of attenuated isolates of Pepino mosaic virus for cross-protection [PDF]
, 2010 Pepino mosaic virus (PepMV) has recently emerged as a highly infectious viral pathogen in tomato crops. Greenhouse trials were conducted under conditions similar to commercial tomato production.
Hamelink, R. +5 more
core +2 more sources
Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo
FEBS Open Bio, EarlyView.The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu +12 more
wiley +1 more source
Acute Infection and Subsequent Subclinical Reactivation of Herpes Simplex Virus 2 after Vaginal Inoculation of Rhesus Macaques. [PDF]
, 2019 Herpes simplex virus 2 (HSV-2) is a common sexually transmitted infection with a highly variable clinical course. Many infections quickly become subclinical, with episodes of spontaneous virus reactivation.
Burgener, Adam +15 more
core
Key role for inhibins in effective T cell activation, migration and Th17 differentiation
FEBS Open Bio, EarlyView.Activins/inhibins modulate immune responses. Here, we show that inhibins can be produced very early after T cell activation and can act in an autocrine way, favoring Th1 versus Th17 differentiation and CCL19/CCL21 mediated migration. Recombinant inhibin A can restore the Th1/Th17 balance, highlighting the role of inhibins as key regulators of T cell ...
Sandra Ortega‐Francisco +5 more
wiley +1 more source