Results 121 to 130 of about 131,372 (308)

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

Zonal localization iNOS in LPS-treated fish.

, 2016
Immunocytochemical analysis showing the localized expression of iNOS in different tissues of H. fossilis after treatment with LPS. Representative pictures of five independent experiments are shown. Nucleus–blue; iNOS–red. Scale bar: 55 μm.
Nirmalendu Saha (500241), Mahua G. Choudhury (500240)   +1 more
core   +1 more source

Redirecting Monocyte Differentiation With Engineered Extracellular Vesicles for Glioma Immunotherapy

Advanced Science, EarlyView.
A dual‐targeting engineered extracellular vesicles (M1‐CS‐EVs) platform is developed to redirect monocytes differentiation into anti‐tumor macrophages for glioma immunotherapy. This nanoplatform combines CAR‐mediated tumor recognition with localized CD47 blockade, leading to synergistic immune activation and potent suppression of tumor progression in ...
Yuanwei Pan, Xuan Liu, Qian‐Fang Meng, Lei Cao, Rongrong Li, Yangtao Xu, Jing Zhang, Chenchen Zhao, Lang Rao, Chen Yu   +9 more
wiley   +1 more source

The role of adipose tissue cell elements in the regulation of the nitroxidergic system and possible ways of pharmacological modulation

Сучасні медичні технології
Endothelial dysfunction is characterized by a decrease in the bioavailability of the vasodilator – nitric oxide (NO), and an increase in the level of vasoconstrictor substances.
I. F. Bielenichev, S. O. Maslennikov, N. V. Dobrelia, O. S. Khromov, M. L. Holovakha, V. P. Ryzhenko, O. O. Brek   +6 more
doaj   +1 more source

Ion‐Driven Regulation of Ca2+ Flow by Ti/Zn Composite Activates ERK/MAPK Signaling and Maintains Mitochondrial Homeostasis to Promote Macrophage‐Mediated Bone Regeneration

Advanced Science, EarlyView.
A 3D‐printed interpenetrating Ti/Zn composite enables sustained Zn2+ release to regulate intracellular Ca2+ redistribution, preserve mitochondrial homeostasis, activate ERK/MAPK signaling, and promote M2 macrophage polarization, thereby enhancing osteoimmune‐mediated bone regeneration and peri‐implant osseointegration.
Wanyi Huang, Qiyue Zhang, Yueyang Qiu, Haocheng Suo, Zengqian Liu, Bing Bai, Qiang Wang, Qing Zhou   +7 more
wiley   +1 more source

Brenthis ino

, 2017
Published as part of Fernández Vidal, Eliseo H., 2017, Lepidópteros de O Courel (Lugo, Galicia, España, N. O. Península Ibérica) XIII: Libytheidae y Nymphalidae (sensu classico). (Insecta: Lepidoptera)., pp.
openaire   +2 more sources

Efficacy of a Standardized Turmeric Extract Comprised of 70% Bisdemothoxy-Curcumin (REVERC3) Against LPS-Induced Inflammation in RAW264.7 Cells and Carrageenan-Induced Paw Edema

Journal of Inflammation Research, 2021
Kuluvar Gouthamchandra,1 Heggar Venkataramana Sudeep,1 Siddappa Chandrappa,2 Amrith Raj,1 Puttaswamy Naveen,3 Kodimule Shyamaprasad1 1Department of Biomedicinal Research, R&D Centre for Excellence, Vidya Herbs Pvt.
Gouthamchandra K, Sudeep HV, Chandrappa S, Raj A, Naveen P, Shyamaprasad K   +5 more
doaj  

Temporal course of LIF-induced iNOS expression.

, 2013
A. Immunofluorescence of iNOS in cells treated with LIF for 0 (a), 6 (b), 12 (c) and 24 h (d). Blue: DAPI nuclear staining. Scale bar: 50 µm. B. qPCR iNOS mRNA treated as in A of three independent experiments expressed as the mean ± SEM of the iNOS ...
Estefania Lopez-Arenas (307531), Lorena Sulz (307532), Alan Mackay-Sim (210039), Juan Bacigalupo (138263)   +3 more
core   +1 more source

Copper‐Doped Prussian Blue Nanozymes With Hyaluronic Acid‐Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy

Advanced Science, EarlyView.
CuPB@HA is a CD44‐associated, plaque‐targeted nanozyme that alleviates oxidative stress, inflammation, and lipid accumulation in macrophages. By reducing CD36‐dependent lipid uptake and promoting ABCA1/ABCG1‐mediated cholesterol handling, it improves macrophage function, preferentially accumulates in atherosclerotic lesions, reduces plaque burden, and ...
Jianliang Ou, Ruihua Ji, Qinglu Zang, Mingkang Wang, Lingling Zhou, Yingliang Wei, Di Yang, Yue Wu, Hongxu Zhu, Jianrong Wu, Xiaojun Cai, Wenxian Du, Junjie Cheng, An Zeng, Yuehua Li   +14 more
wiley   +1 more source

Ino

, 2012
Source: Johann Friedrich Reichardt: Ino. Ein Melodrama von Herrn Brandes, in: Melodramen, Nr. 4, Pilsen: [o. V.], 1791, S. 75–107.
openaire   +1 more source