Results 141 to 150 of about 131,372 (308)

Programmable Paracrine‐Mimetic Microneedle System for Temporal Regulation of Cardiac Repair

Advanced Science, EarlyView.
Temporal signaling is encoded into a programmable paracrine‐mimetic microneedle patch via tris(2,2'‐bipyridyl)dichlororuthenium(II) hexahydrate/sodium persulfate‐tuned hydrogel microparticles that deliver TGF‐β, IGF‐1, and VEGF over phase‐matched 7‐, 14‐, and 28‐day windows.
Yichen Dai, Pengchong Du, Zhaoyang Wang, Surilige, Rangga Fokta, Renjian Tan, Xiqing Zhao, Shuoyi Zhang, Yuecheng Wang, Yixin Zhang, Ziliang Fu, Rui Gong, Cheng Jiang, Yisheng He, Qiguang Wang, Renke Li, Khoon Lim, Junnan Tang, Xiaolin Cui   +18 more
wiley   +1 more source

KLF6 and iNOS regulates apoptosis during respiratory syncytial virus infection

, 2013
•Transactivation of iNOS gene by KLF6 during respiratory syncytial virus infection.•KLF6 is required for optimal apoptosis during respiratory syncytial virus infection.•iNOS/nitric oxide promotes apoptosis during respiratory syncytial virus infection ...
Chang, Te-Hung, Bose, Santanu, Mgbemena, Victoria, Segovia, Jesus   +3 more
core   +1 more source

A Multidimensional Engineering Strategy Reprograms Microglia via Targeted and Sustained‐Release Extracellular Vesicles for Spinal Cord Injury Repair

Advanced Science, EarlyView.
A multifunctional EV‐based nanoplatform (Ang‐TEVs@Gel) was engineered via preconditioning, surface targeting, and ROS‐responsive hydrogel encapsulation to reprogram microglia. This system restored autophagy via miR‐664a‐3p/PIK3CA axis, cleared myelin debris, resolved neuroinflammation, and promoted axon remyelination, ultimately achieving robust motor ...
Wu Xiong, Minhao Liu, Mingming Zheng, Jizhou Jia, Ziyan Zhu, Guang Kong, Jie Liu, Juan Wang, Wenbo Li, Qingyuan Wang, Qian Zhu, Peiran Chan, Tao Qin, Jiayang Wu, Yongjie Zhang, Chunming Tang, Cong Li, Jin Fan   +17 more
wiley   +1 more source

Correction: Non-peptide compounds from Kronopolites svenhedini (Verhoeff) and their antitumor and iNOS inhibitory activities

Beilstein Journal of Organic Chemistry, 2023
Yuan-Nan Yuan, Jin-Qiang Li, Hong-Bin Fang, Shao-Jun Xing, Yong-Ming Yan, Yong-Xian Cheng   +5 more
doaj   +1 more source

Alternating Shear Force of Respiration Regulates Cell Interactions of Fibroblasts and Macrophages to Promote Soft Tissue Integration of Chest Wall Polyetheretherketone Implants

Advanced Science, EarlyView.
Given that PEEK chest wall implants induce shear force at the soft tissue‐implant interface due to respiratory motion in the early in vivo post‐implantation stage. We confirmed that this mechanical stimulus triggers the PIEZO1/ITGB1/YAP1 signalling axis in L929 and the STAT6/p‐STAT6 pathway in RAW264.7, which in turn mediates adhesion and migration of ...
Rou Huang, Yangfan Huo, Jin Liu, Sida Liu, Minghai Ma, Hao Guo, Yuanquan Zhang, Xing Li, Xiao Liang, Jiawei Xiu, Ying Sun, Lijun Huang, Xiaolong Yan, Weiwei Wu, Lei Wang   +14 more
wiley   +1 more source

INO [PDF]

Proceedings of 16th International Workshop on Neutrino Factories and Future Neutrino Beam Facilities — PoS(NUFACT2014), 2015
openaire   +1 more source

Dennantia ino

Published as part of Darragh, Thomas A., 2024, A checklist of Australian marine Cenozoic Mollusca, pp. 37-206 in Memoirs of Museum Victoria 83 on page 99, DOI: 10.24199/j.mmv.2024.83.02, http://zenodo.org/record ...
openaire   +2 more sources

Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro.

, 1994
Cellular constituents of heart muscle contain both constitutive and inducible nitric oxide (NO) signaling pathways that modulate the contractile properties of cardiac myocytes.
Kapturczak, M, Balligand, Jean-Luc, Davidoff, A J, Pimental, D, Taha, Z, Malinski, T A, Kelly, R A, Ungureanu-Longrois, D, Simmons, W W, Lowenstein, C J   +9 more
core  

TNF-α and IFN-γ primed iNOS Gene Expression Dynamics.

, 2016
The model was simulated with TNF-α, IFN-γ, or both TNF-α /IFN-γ for 24 simulation hours to prime the system. The concentrations of iNOS transcription factors, iNOS mRNA, and iNOS protein were used as inputs to the system for an 8-hour addition simulation
Taha Salim (2825270), Elebeoba E. May (2825273), Cheryl L. Sershen (350195)   +2 more
core   +1 more source

Versatile Co‐Engineering of Immunogenic Cell Death‐Primed Dead Tumor Cell Bodies With Tumor‐Activated MnO2 for cGAS‐STING‐Potentiated Personalized Immunotherapy

Advanced Science, EarlyView.
DTBEI@CS@MnO2, fabricated via modular electrostatic co‐engineering and photothermal/photodynamic immunogenic cell death, specifically responds to the acidic and GSH‐rich tumor microenvironment. This triggers the release of DTBEI that provides tumor antigens, DNA, and DAMPs, as well as the generation of Mn2+, thereby synergistically potentiating cGAS ...
Bolun Xu, Xuan Lu, Yuquan Wang, Haihua Ji, Ying Zhang, Yiqun Wan, Hao Wan   +6 more
wiley   +1 more source