Results 51 to 60 of about 131,372 (308)

Protein‐Nanoarchitectures for Low‐Field Intracellular Electro‐Immunomodulation

Advanced Functional Materials, EarlyView.
DHQ‐SDH‐mediated binding of AuNPs drives the formation of interconnected, chain‐like nanoarchitectures with enhanced electrical conductivity. These conductive assemblies undergo macrophage uptake and enable low‐field electrical stimulation, promoting M1‐to‐M2 phenotypic switching with decreased iNOS and increased CD206 expression. Such protein‐mediated
Viktoriya Pakharenko, Djanira Rodrigues Negrão, Tanmay Gupta, Robert Jeng, Otavio Augusto Titton Dias, Maia Jaffer‐Diaz, Dinesh Christendat, Mohini Sain   +7 more
wiley   +1 more source

Aloe Extracts Inhibit Skin Inflammatory Responses by Regulating NF-κB, ERK, and JNK Signaling Pathways in an LPS-Induced RAW264.7 Macrophages Model

Clinical, Cosmetic and Investigational Dermatology, 2023
Fei Wang,1– 3,* Jitao Liu,1– 3 Quan An,1– 4,* Yiming Wang,1– 3 Yang Yang,1– 3 Tong Huo,1– 3 Simin Yang,5 Ruijun Ju,5 Qianghua Quan1– 4 1Research and Development Department, Yunnan Baiyao Group Health Products Co., Ltd., Kunming, People’s Republic
Wang F, Liu J, An Q, Wang Y, Yang Y, Huo T, Yang S, Ju R, Quan Q   +8 more
doaj  

RETRACTED: iNOS is associated with tumorigenicity as an independent prognosticator in human intrahepatic cholangiocarcinoma

, 2019
Background: Inducible nitric oxide synthase (iNOS) has supposed to implicate in inflammation, infection, liver cirrhosis, and neoplastic diseases.
Jiang, Jinqiong, Li, Hao, Liu, Sulai, Zou, Lianhong, Jiang, Bo, Huang, Linsheng, Peng, Chuang, Yu, Xing, Lv, Yuan, Liu, Xiehong, Jiang, Yu, Yu, Nanhui   +11 more
core   +1 more source

Targeting CD300a Signaling With a Phosphatidylserine‐Presenting Hydrogel Rescues Macrophage Dysfunction and Accelerates Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the proposed mechanism: PEG/RGD‐PSLs mimic apoptotic cells to engage PS receptors (notably CD300a), transducing an inhibitory signal that suppresses the MyD88/NF‐κB pathway, leading to global anti‐inflammatory and pro‐reparative effects.
Lele Wu, Xuetong Hao, Yang Zou, Xinglin Chen, Junyan Kong, Chunning Gu, Wenjie Ma, Zhongjun Yang, Huifen Liu, Mengmeng Liu, Xin Tong   +10 more
wiley   +1 more source

PLL‐g‐HPA Hydrogel Microneedles Loaded With Rhoifolin Target Macrophages to Alleviate Fibroblast Senescence for Diabetic Wound Healing

Advanced Healthcare Materials, EarlyView.
Diabetic wound healing is hindered by a pathological crosstalk wherein elevated IL‐11 induces M1 macrophage polarization, leading to IL‐1β/IL‐6 release and subsequent fibroblast senescence via RAS/p38MAPK/p53/E2F1 signaling. Here, we develop a Gel@M‐Rho microneedle patch that delivers rhoifolin‐loaded, macrophage membrane‐coated nanoparticles to target
Jiewen Liao, Lin Gan, Li Lu, Lizhi Ouyang, Yuan Xiong, Fawwaz Al‐Smadi, Guandong Dai, Mohammad‐Ali Shahbazi, Bobin Mi, Mengfei Liu, Guohui Liu   +10 more
wiley   +1 more source

4-(1-Methylamino)ethylidene-1,5-disubstituted pyrrolidine-2,3-diones: synthesis, anti-inflammatory effect and in silico approaches

Beilstein Journal of Organic Chemistry
Pyrrolidine-2,3-diones are important intermediates in the synthesis of numerous nitrogen-containing heterocycles which possess a broad spectrum of biological and pharmacological activities.
Nguyen Tran Nguyen, Vo Viet Dai, Luc Van Meervelt, Do Thi Thao, Nguyen Minh Thong   +4 more
doaj   +1 more source

MOLECULAR DOCKING OF CROCUS SATIVUS PHYTOCHEMICALS AGAINST INDUCIBLE NITRIC OXIDE SYNTHASE AND PHOSPHODIESTERASE-9 IN HEART FAILURE PRESERVED EJECTION FRACTION

Majalah Biomorfologi, 2023
Highlights 1. Heart failure preserved ejection fraction increases the mortality rate every year. 2. Definitive therapy for HFpEF is not well identified. 3.
Syafira Yasmine, Neissya Nastiti Firmanto, Annisa Maya Sabrina, Siti Khaerunnisa   +3 more
doaj   +1 more source

Similarity of duck iNOS to iNOS in other species.

, 2013
Similarity of duck iNOS to iNOS in other species.
Simon Burggraaf (357369), John Bingham (331842), Jean Payne (145840), John W. Lowenthal (331847), Andrew G. D. Bean (357371), Wayne G. Kimpton (357370)   +5 more
core   +1 more source

Water‐Activated Phospholipid Phase‐Separation Gel as an Immunomodulatory Anti‐Adhesion Barrier for Postoperative Adhesion Prevention

Advanced Healthcare Materials, EarlyView.
A water‐activated phospholipid phase‐separation gel is repurposed as a drug‐free surgical barrier for postoperative adhesion prevention. Propylene glycol promotes rapid lamellar gel reinforcement, prolonged local retention, and tissue coverage, while phosphatidylcholine‐mediated immunomodulation suppresses inflammatory and fibrotic responses. This dual‐
Jong‐Ju Lee, Yulseung Sung, Yeji Kim, Heesang Yang, Suyeon Pyo, Byeol Yun, Sung‐Joo Hwang   +6 more
wiley   +1 more source

Near‐Infrared Light‐Activated Polydopamine Nanoparticles Conjugated With Transferrin Peptides for Enhanced Brain Accumulation

Advanced Healthcare Materials, EarlyView.
This study demonstrates that Tf‐PDA NPs combine a receptor‐mediated targeting with mild photothermal activation to enhance nanoparticle accumulation in the brain. NIR‐activated Tf‐PDA NPs increase BBB permeability to NPs in vitro and in vivo without inducing cytotoxicity or adverse immune responses.
Rafaela Ferrão, Susana Simões, Paulo Rodrigues‐Santos, Vitor Francisco, Akhilesh Rai, Lino Ferreira   +5 more
wiley   +1 more source