Results 151 to 160 of about 71,261 (330)

Influence of nonsteroid anabolic inosine on manifestation of the effects of dexamethasone on skeletal muscle of white rats

open access: yesБіологічні студії, 2012
In experiments on young rat females, it has been established, that the nonsteroid anabolic inosine caused in the case of complex application with dexamethasone the increasing of a specific fraction of slow or intermediate type of fibers in initially ...
V. V. Trush
doaj   +1 more source

Glutaminase‐1 Mediated Glutaminolysis to Glutathione Synthesis Maintains Redox Homeostasis and Modulates Ferroptosis Sensitivity in Cancer Cells

open access: yesCell Proliferation, EarlyView.
GLS1‐mediated glutaminolysis supports GSH synthesis in cancer cells. GLS1 KO increases ROS, downregulates GPX4, and upregulates GPX1, making cells more sensitive to ferroptosis. Combining GLS1 or GPX1 inhibitors with a GPX4 inhibitor synergistically suppresses cancer growth.
Changsen Bai   +13 more
wiley   +1 more source

Inhibition of inosine metabolism of the gut microbiota decreases testosterone secretion in the testis

open access: yesmSystems
Growing evidence indicates that gut microbiota is involved in the regulation of the host’s sex hormone levels, such as through interfering with the sex hormone metabolism in the intestine.
Lei Tang   +8 more
doaj   +1 more source

Rapid, Diagnostic Test for Cardiac Ischemia [PDF]

open access: yes, 2017
Current methods to detect cardiac ischemia rely on biomarkers such as troponin. Elevated levels of troponin are observed hours after the cardiac event.
Contreras, Julio   +4 more
core   +2 more sources

Enzymic Synthesis of Xanthosine- and Guanosine-5-phosphate from Inosine-5-phosphate. [PDF]

open access: bronze, 1955
Ulf Lagerkvist   +3 more
openalex   +1 more source

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

open access: yesACS Infectious Diseases, 2016
VCC234718, a molecule with growth inhibitory activity against Mycobacterium tuberculosis (Mtb), was identified by phenotypic screening of a 15344-compound library.
Vinayak Singh   +21 more
semanticscholar   +1 more source

Stress exposure in the mdx mouse model of Duchenne muscular dystrophy provokes a widespread metabolic response

open access: yesThe FEBS Journal, EarlyView.
A targeted mass spectrometry‐based metabolomics assay was conducted to identify the impact of stress exposure on the regulation of biological stress pathways in the mdx mouse model of Duchenne muscular dystrophy. We demonstrated a broad shift in the circulating stress‐relevant plasma metabolome associated with stressful scruff handling that was ...
Erynn E. Johnson, James M. Ervasti
wiley   +1 more source

Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism

open access: yesThe FEBS Journal, EarlyView.
IMPDH, the rate‐limiting enzyme for de novo GTP synthesis, can form polymers and cytoophidia to enhance activity by reducing GTP inhibition. In this study, a Y12C mutation in IMPDH2 was introduced via ABEmax base‐editing in human cancer cell lines to disrupt IMPDH polymerisation.
Chia‐Chun Chang   +7 more
wiley   +1 more source

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