Results 191 to 200 of about 71,261 (330)

Gut Microbiota Reshapes the Tumor Microenvironment and Affects the Efficacy of Colorectal Cancer Immunotherapy

open access: yesCancer Medicine, Volume 14, Issue 12, June 2025.
ABSTRACT Background Colorectal cancer (CRC) is among the most prevalent malignant tumors in the digestive system and is the third leading cause of cancer‐related mortality. In recent years, immunotherapy has markedly enhanced the objective response and survival rates for CRC patients.
Fayuan Wang   +13 more
wiley   +1 more source

Efficacy of inosine pranobex in frequently ill children with chronic Epstein–Barr virus infection: randomized study

open access: yesВопросы современной педиатрии, 2011
High incidence of acute respiratory infections (ARI) in immunocompromised frequently ill children with chronic Epstein–Barr infection forces the prescription of drugs with complex antivirus and immunocorrecting effect.
E.N. Simovanyan   +2 more
doaj  

Causal Relationship Between Gut Microbiota, Blood Metabolites, and Intervertebral Disc Degeneration: A Two‐Step, Two‐Sample Bidirectional Mendelian Randomization Study

open access: yesJOR SPINE, Volume 8, Issue 2, June 2025.
We have identified several specific gut microbiota that may have an effect on intervertebral disc degeneration, and have found possible blood metabolites that mediate the effects of the gut microbiota on intervertebral disc degeneration. This study provides new insights into the mechanisms by which gut microbes are involved in the development of ...
Yi‐Ping Zheng   +6 more
wiley   +1 more source

Loss of Adenosine Deaminase Acting on RNA 1 Induces Panoptosis and Immune Response in Ulcerative Colitis Gut Mucosa

open access: yesMedComm, Volume 6, Issue 6, June 2025.
The gut virome is a complex community that, when disrupted, may contribute to inflammatory diseases like IBD. We found that ADAR1 expression is reduced in gut inflamed mucosa of ulcerative colitis patients. ADAR1 silencing heightened activation of inflammatory pathways and PANoptosis exacerbating gut tissue damage, but JAK inhibition or AhR activation ...
Andrea Iannucci   +13 more
wiley   +1 more source

ON INOSINIC ACID

open access: yesJournal of Biological Chemistry, 1929
P.A. Levene, T. Mori
openaire   +2 more sources

Mitochondrial Ribosomal Protein Family in Cancers: Mechanistic Insights and Therapeutic Implications

open access: yesMedComm – Oncology, Volume 4, Issue 2, June 2025.
Mitochondrial ribosomal proteins (MRPs) are the important components of mitoribosome. They are aberrantly expressed in various human cancers. In this review, we introduce the roles of MRPs in tumorigenesis and development by regulating OXPHOS and other mechanisms.
Qian Chen   +3 more
wiley   +1 more source

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