Cell Proliferation, EarlyView.During skeletal muscle ageing, down‐regulation of TRα expression activates IP3R1 transcriptional expression, promotes MAM calcium transport, triggers mitochondrial calcium overload and apoptosis, leading to skeletal muscle atrophy. Restoring TRα expression can improve IP3R1‐mediated mitochondrial calcium overload and apoptosis in ageing skeletal muscle
Runqing Shi +7 more
wiley +1 more source
Low carbohydrate and low-calorie diets reduce liver fat and lower brain glutamate and myo-inositol levels in patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). [PDF]
Metab Brain DisHaley AP +8 more
europepmc +1 more source
The Effect of Inositol Hexaphosphate on the Kinetics of CO and O2 Binding by Human Hemoglobin
, 1971 Robert D. Gray, Quentin Gibson
openalex +1 more source
PI5P4K inhibitors: promising opportunities and challenges
The FEBS Journal, EarlyView.Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi +16 more
wiley +1 more source
The Role of Pharmacists in Identifying and Preventing Drug-Related Problems in PCOS Management. [PDF]
Pharmacy (Basel)Lebanova H, Yanachkova V, Stoev S.
europepmc +1 more source
Isoproterenol modulates insulin activation of insulin receptor kinase in intact rat adipocytes [PDF]
, 1988 Klein, H. H. +2 more
core
Epigenetic control of cell identities from epiblast to gastrulation
The FEBS Journal, EarlyView.In this review, we present and contextualize current knowledge about the roles of epigenetic modifiers during the development of mouse epiblast to gastrulation stage. The epigenetic regulation of enhancer and promoter elements by DNA methylation, histone modifications, and chromatin accessibility in concert with lineage‐specific transcription factors ...
Katrin M. Schüle, Simone Probst
wiley +1 more source
Tandem inactivation of inositol pyrophosphatases Asp1, Siw14, and Aps1 illuminates functional redundancies in inositol pyrophosphate catabolism in fission yeast. [PDF]
mBioSchwer B +5 more
europepmc +1 more source
The FEBS Journal, EarlyView.Using CRISPR‐Cas9, we engineered a genetic system allowing the dose‐dependent induction of a controllable number of DNA double‐strand breaks in Saccharomyces cerevisiae. The tool was used to study the kinetics of DNA break sensing and repair, including the spatial distribution of Tel1ATM kinase, which initiates the DNA damage response.
Morgane Auboiron +5 more
wiley +1 more source