Results 81 to 90 of about 58,268 (235)

Role of Inositol-1,4,5-Trisphosphate Receptor in the Regulation of Calcium Transients in Neonatal Rat Ventricular Myocytes

Journal of Pharmacological Sciences, 2014
This study determined the regulatory effect of inositol 1,4,5-trisphosphate receptors (IP3Rs) on the basal Ca2+ transients in cardiomyocytes. In cultured neonatal rat ventricular myocytes (NRVMs) at different densities, we used confocal microscopy to ...
Zheng Zeng, Heping Zhang, Na Lin, Man Kang, Yuanyuan Zheng, Chen Li, Pingxiang Xu, Yongquan Wu, Dali Luo   +8 more
doaj   +1 more source

Phosphoinositides in Retinal Function and Disease

Cells, 2020
Phosphatidylinositol and its phosphorylated derivatives, the phosphoinositides, play many important roles in all eukaryotic cells. These include modulation of physical properties of membranes, activation or inhibition of membrane-associated proteins ...
Theodore G. Wensel
doaj   +1 more source

The nitty‐gritty of vascular permeability in cancer: targeting blood endothelium to control metastases

British Journal of Pharmacology, EarlyView.
Blood vascular permeability is a hallmark of cancer and acts as an active driver of metastatic dissemination. Metastasis accounts for the vast majority of cancer deaths, yet most work has focussed on tumour‐intrinsic traits and angiogenesis, while the specific contribution of endothelial barrier regulation to intravasation and extravasation remains ...
Pierre Boucher, Mérone Da Costa Oliveira, Adrien Levesque, Alexandre Rutault, Patrick Savoyaud, Nicolas Bréchot, Stéphane Germain   +6 more
wiley   +1 more source

Functional Role of Intracellular Calcium Receptor Inositol 1,4,5-Trisphosphate Type 1 in Rat Hippocampus after Neonatal Anoxia. [PDF]

PLoS ONE, 2017
Anoxia is one of the most prevalent causes of neonatal morbidity and mortality, especially in preterm neonates, constituting an important public health problem due to permanent neurological sequelae observed in patients.
Juliane Midori Ikebara, Silvia Honda Takada, Débora Sterzeck Cardoso, Natália Myuki Moralles Dias, Beatriz Crossiol Vicente de Campos, Talitha Amanda Sanches Bretherick, Guilherme Shigueto Vilar Higa, Mariana Sacrini Ayres Ferraz, Alexandre Hiroaki Kihara   +8 more
doaj   +1 more source

Activation Mechanisms and Diverse Functions of Mammalian Phospholipase C

Biomolecules, 2023
Phospholipase C (PLC) plays pivotal roles in regulating various cellular functions by metabolizing phosphatidylinositol 4,5-bisphosphate in the plasma membrane. This process generates two second messengers, inositol 1,4,5-trisphosphate and diacylglycerol,
Kaori Kanemaru, Yoshikazu Nakamura
doaj   +1 more source

Inositol 1,4,5-trisphosphate receptor subtypes differentially recognize regioisomers of D-myo-inositol 1,4,5-trisphosphate

Biochemical Journal, 1997
The Ins(1,4,5)P3 regioisomers, Ins(1,4,6)P3 and Ins(1,3,6)P3, which can mimic the 1,4,5-arrangement on the inositol ring of Ins(1,4,5)P3, were examined for Ca2+ release by using four types of saponin-permeabilized cell possessing various abundances of receptor subtypes, with special reference to the relation of potency to receptor subtype. Ins(1,4,6)P3
M, Hirata, H, Takeuchi, A M, Riley, S J, Mills, Y, Watanabe, B V, Potter   +5 more
openaire   +3 more sources

Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase

, 2002
Calcium metabolism regulation may be studied by use of a novel purine-based inhibitor of inositol 1,4,5-trisphosphate 3-kinase (IP3K) developed by purine library screening (IC50= 10.2 muM). This new IP3K inhibitor 1 increased Ca2+ ion release as a result
Choi, Gildon, Gray, NS, Cox, RJ, Moon, Ho-Sang, Choi, Kwan Yong, Chung, SK, Ryu, Sung Ho, Burdett, Matthew, Gray, Nathanael S., Chung, Sung-Kee, Ryu, SH, Suh, PG, Bae, Yoe-Sik, Schultz, Peter G., Choi, G, Meijer, Laurent, Mogk, Axel, Mayo-Martin, MB, Lee, Jae Wook, Schultz, PG, Waldmann, H., Chang, Young-Tae, Eisele, F., Burdett, M, Suh, Pann-Ghill, CHANG, YOUNG TAE, Meijer, L, Deuerling, Elke, Bae, YS, Ludolph, B., Gibson, JS, Mayer, Matthias P., Moon, HS, Lee, JW, Choi, KY   +34 more
core   +1 more source

Dominant mutations in ITPR3 cause Charcot‐Marie‐Tooth disease

Annals of Clinical and Translational Neurology, 2020
Objective ITPR3, encoding inositol 1,4,5‐trisphosphate receptor type 3, was previously reported as a potential candidate disease gene for Charcot‐Marie‐Tooth neuropathy. Here, we present genetic and functional evidence that ITPR3 is a Charcot‐Marie‐Tooth
Julius Rönkkö, Svetlana Molchanova, Anya Revah‐Politi, Elaine M. Pereira, Mari Auranen, Jussi Toppila, Jouni Kvist, Anastasia Ludwig, Julika Neumann, Geert Bultynck, Stéphanie Humblet‐Baron, Adrian Liston, Anders Paetau, Claudio Rivera, Matthew B. Harms, Henna Tyynismaa, Emil Ylikallio   +16 more
doaj   +1 more source

ER proteostasis meets mitochondrial function: contact sites as hubs of communication and therapeutic targets

The FEBS Journal, EarlyView.
Proteostasis ensures proper protein folding, modification, and degradation, while its impairment triggers ER stress. Chronic ER stress and maladaptive UPR via the CHOP–ERO1 axis remodel ERMCs, altering calcium signaling and mitochondrial metabolism.
Giorgia Maria Renna, Alessandro Cherubini, Ersilia Varone, Serena Germani, Alice Marrazza, Ester Zito   +5 more
wiley   +1 more source

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source