Regulatory effects of inositol 1,4,5-trisphosphate receptor genes knockdown on intracellular Ca²⁺ concentration and ion channel–related gene expression in duck uterine epithelial cells [PDF]
Poultry ScienceThis study employed primary uterine epithelial cells from Sansui ducks (Anas platyrhynchos) at the peak of lay as an in vitro model. Using shRNA-mediated interference, we generated single knockdowns of inositol 1,4,5-trisphosphate receptor type 1 (IP3R1),
Yong Zhao +5 more
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Molecular determinants of peri‐apical targeting of inositol 1,4,5‐trisphosphate receptor type 3 in cholangiocytes [PDF]
Hepatology Communications, 2022 Fluid and bicarbonate secretion is a principal function of cholangiocytes, and impaired secretion results in cholestasis. Cholangiocyte secretion depends on peri‐apical expression of the type 3 inositol trisphosphate receptor (ITPR3), and loss of this ...
Michele A. Rodrigues +8 more
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Inositol-1,4,5-Trisphosphate Receptor-1 and -3 and Ryanodine Receptor-3 May Increase Ooplasmic Ca2+ During Quail Egg Activation [PDF]
The Journal of Poultry Science, 2022 We previously reported that egg activation in Japanese quail is driven by two distinct types of intracellular Ca2+ ([Ca2+]i): transient elevations in [Ca2+]i induced by phospholipase Czeta 1 (PLCZ1) and long-lasting spiral-like Ca2+ oscillations by ...
Shusei Mizushima +4 more
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Inositol 1,4,5-Trisphosphate Receptor Type 3 Regulates Neuronal Growth Cone Sensitivity to Guidance Signals [PDF]
iScience, 2020 Summary: During neurodevelopment, the growth cone deciphers directional information from extracellular guidance cues presented as shallow concentration gradients via signal amplification.
Carmen Chan +8 more
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Inositol 1,4,5-Trisphosphate Receptor 1 Gain-of-Function Increases the Risk for Cardiac Arrhythmias in Mice and Humans [PDF]
CirculationJosefina Ramos-Franco +2 more
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Cryo-EM structure of type 1 IP3R channel in a lipid bilayer
Communications Biology, 2021 3D structure of full-length rat type 1 inositol 1,4,5-trisphosphate receptor reconstituted in lipid nanodisc is determined using single-particle cryo-electron microscopy.
Mariah R. Baker +5 more
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Asian Journal of Andrology, 2020 The acrosome reaction is a prerequisite for fertilization, and its signaling pathway has been investigated for decades. Regardless of the type of inducers present, the acrosome reaction is ultimately mediated by the elevation of cytosolic calcium ...
Ying-Ya Li +3 more
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Inositol 1,4,5- trisphosphate receptor function in Drosophila insulin producing cells. [PDF]
PLoS ONE, 2009 The Inositol 1,4,5- trisphosphate receptor (InsP(3)R) is an intracellular ligand gated channel that releases calcium from intracellular stores in response to extracellular signals.
Neha Agrawal +2 more
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Inositol 1,4,5-Trisphosphate Receptor Mutations Associated with Human Disease [PDF]
Messenger (Los Angeles, Calif: Print), 2018 Lara Terry +2 more
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Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by analogues of IP3. [PDF]
PLoS ONE, 2013 Most animal cells express mixtures of the three subtypes of inositol 1,4,5-trisphosphate receptor (IP(3)R) encoded by vertebrate genomes. Activation of each subtype by different agonists has not hitherto been examined in cells expressing defined ...
Huma Saleem +5 more
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