Results 11 to 20 of about 1,279,181 (240)
Role of the inositol 1,4,5-trisphosphate receptor/Ca2+-release channel in autophagy
Cell Communication and Signaling, 2012 Autophagy is an important cell-biological process responsible for the disposal of long-lived proteins, protein aggregates, defective organelles and intracellular pathogens.
Parys Jan B +2 more
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Inositol 1,4,5-trisphosphate receptor expression in odontoblast cells [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1997 The cellular distribution of inositol 1,4,5-trisphosphate receptors was examined in rodent maxillary incisor teeth. In situ hybridization studies with a transmembrane probe of type I inositol 1,4,5-trisphosphate receptor indicated that this receptor/channel was highly expressed in odontoblast cells of incisor teeth.
Smutzer, Gregory +6 more
openaire +3 more sources
Inositol 1,4,5-Trisphosphate Receptors in Hypertension [PDF]
Frontiers in Physiology, 2018 Chronic hypertension remains a major cause of global mortality and morbidity. It is a complex disease that is the clinical manifestation of multiple genetic, environmental, nutritional, hormonal, and aging-related disorders. Evidence supports a role for vascular aging in the development of hypertension involving an impairment in endothelial function ...
Ali H. Eid +10 more
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STAR Protocols, 2021 Summary: This protocol outlines steps to visualize and detect Ca2+ puffs following photo-liberation of caged inositol-1,4,5-trisphosphate (IP3) from HEK-293 cells expressing only the native IP3R type 1 receptor using total internal reflection ...
Vikas Arige +4 more
doaj +1 more source
Inositol 1,4,5-trisphosphate receptor in the liver: Expression and function. [PDF]
World J Gastroenterol, 2019 The liver is a complex organ that performs several functions to maintain homeostasis. These functions are modulated by calcium, a second messenger that regulates several intracellular events. In hepatocytes and cholangiocytes, which are the epithelial cell types in the liver, inositol 1,4,5-trisphosphate (InsP3) receptors (ITPR) are the only ...
Lemos FO +4 more
europepmc +3 more sources
Mitochondria-Endoplasmic Reticulum Interplay Regulates Exo-Cytosis in Human Neuroblastoma Cells
Cells, 2022 Mitochondria–endoplasmic reticulum (ER) contact sites (MERCS) have been emerging as a multifaceted subcellular region of the cell which affects several physiological and pathological mechanisms.
Giacomo Dentoni +2 more
doaj +1 more source
Inositol 1,4,5‐trisphosphate receptors and neurodegenerative disorders [PDF]
The FEBS Journal, 2018 The inositol 1,4,5‐trisphosphate receptor (IP3R) is an intracellular ion channel that mediates the release of calcium ions from the endoplasmic reticulum. It plays a role in basic biological functions, such as cell division, differentiation, fertilization and cell death, and is involved in developmental processes including learning, memory and behavior.
Polina A, Egorova, Ilya B, Bezprozvanny
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Decavanadate displaces inositol 1,4,5-trisphosphate (IP3) from its receptor and inhibits IP3 induced Ca2+ release in permeabilized pancreatic acinar cells [PDF]
, 1991 Inositol 1,4,5-trisphosphate (IP3) induced Ca2+ release in digitonin permeabilized rat pancreatic acinar cells is specifically inhibited by decavanadate.
M. Gratzl +9 more
core +1 more source
Activating calcium release through inositol 1,4,5-trisphosphate receptors without inositol 1,4,5-trisphosphate [PDF]
Proceedings of the National Academy of Sciences, 2002 Cytosolic calcium (Ca2+) is a focal point of many signal transduction pathways and modulates a diverse array of cellular activities ranging from fertilization to cell death (1). Cells generate Ca2+ signals through both internal and external Ca2+ sources.
Bootman, M.D. +2 more
openaire +2 more sources
Journal of Advanced Research, 2020 TMEM16A Ca2+-activated Cl− channels are expressed in pancreatic acinar cells and participate in inflammation-associated diseases. Whether TMEM16A contributes to the pathogenesis of acute pancreatitis (AP) remains unknown.
Qinghua Wang +13 more
doaj +1 more source