Cardiac inositol 1,4,5-trisphosphate receptors
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2017 Calcium is a second messenger that regulates almost all cellular functions. In cardiomyocytes, calcium plays an integral role in many functions including muscle contraction, gene expression, and cell death. Inositol 1,4,5-trisphosphate receptors (IP3Rs) are a family of calcium channels that are ubiquitously expressed in all tissues. In the heart, IP3Rs
M Iveth, Garcia, Darren, Boehning
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The Role of FAK ( Focal Adhesion Kinase) in Fertilization of Starfish Asterina Miniata PLC [PDF]
Engineering and Technology Journal, 2015 Fertilization need increased the concentration of Ca+ for egg activation. Inositol 1,4,5- trisphosphate (IP3), the second messenger of phospholipase Cγ, regulates the initial calcium rise from egg’s endoplasmic reticulum.
Rana Hussein Naser Al-Qaysi
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The Inositol- 1,4,5=Trisphosphate System Is Involved in Rapid Effects of Aldosterone in Human Mononuclear Leukocytes [PDF]
, 1993 There is increasing evidence for rapid steroid action on electrolyte transport in human mononuclear leukocytes (HML). In HML, aldosterone stimulates the Na+/H+ antiporter within a few minutes. Because a variety of hormones and growth factors activate the
Wehling, Martin +5 more
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Stimulation of inositol 1,4,5-trisphosphate (IP3) receptor subtypes by adenophostin A and its analogues. [PDF]
PLoS ONE, 2013 Inositol 1,4,5-trisphosphate receptors (IP3R) are intracellular Ca(2+) channels. Most animal cells express mixtures of the three IP3R subtypes encoded by vertebrate genomes.
Huma Saleem +4 more
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Serotonergic signals enhanced hamster sperm hyperactivation
The Journal of Reproduction and Development, 2021 In the present study, we investigated the regulatory mechanisms underlying sperm hyperactivation enhanced by 5-hydroxytryptamine (5-HT) in hamsters. First, we examined the types of 5-HT receptors that regulate hyperactivation.
Chiyori SAKAMOTO +3 more
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Selective determinants of inositol 1,4,5‐trisphosphate and adenophostin A interactions with type 1 inositol 1,4,5‐trisphosphate receptors [PDF]
British Journal of Pharmacology, 2010 BACKGROUND AND PURPOSEAdenophostin A (AdA) is a potent agonist of inositol 1,4,5‐trisphosphate receptors (IP3R). AdA shares with IP3the essential features of all IP3R agonists, namely structures equivalent to the 4,5‐bisphosphate and 6‐hydroxyl of IP3, but the basis of its increased affinity is unclear.
Rossi, A +4 more
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Journal of Pharmacological Sciences, 2014 This study determined the regulatory effect of inositol 1,4,5-trisphosphate receptors (IP3Rs) on the basal Ca2+ transients in cardiomyocytes. In cultured neonatal rat ventricular myocytes (NRVMs) at different densities, we used confocal microscopy to ...
Zheng Zeng +8 more
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Dominant mutations in ITPR3 cause Charcot‐Marie‐Tooth disease
Annals of Clinical and Translational Neurology, 2020 Objective ITPR3, encoding inositol 1,4,5‐trisphosphate receptor type 3, was previously reported as a potential candidate disease gene for Charcot‐Marie‐Tooth neuropathy. Here, we present genetic and functional evidence that ITPR3 is a Charcot‐Marie‐Tooth
Julius Rönkkö +16 more
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Inositol 1,4,5-trisphosphate 3-kinase A overexpressed in mouse forebrain modulates synaptic transmission and mGluR-LTD of CA1 pyramidal neurons. [PDF]
PLoS ONE, 2018 Inositol 1,4,5-trisphosphate 3-kinase A (IP3K-A) regulates the level of the inositol polyphosphates, inositol trisphosphate (IP3) and inositol tetrakisphosphate to modulate cellular signaling and intracellular calcium homeostasis in the central nervous ...
Byungil Choi +10 more
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Structure and Function of Inositol 1,4,5-Trisphosphate Receptor
Japanese Journal of Pharmacology, 1997 Generation of intracellular Ca2+ signals in response to Ca(2+)-mobilizing stimuli is a critical event in the control of many cellular processes. Inositol 1,4,5-trisphosphate (IP3) represents a dominant second messenger subserving the release of Ca2+ from intracellular store sites.
Yoshida, Yutaka, Imai, Shoichi
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