Results 41 to 50 of about 1,279,181 (240)

Inositol 1,4,5-trisphosphate receptors in cardiomyocyte physiology and disease

Philosophical Transactions of the Royal Society B: Biological Sciences, 2022
The contraction of cardiac muscle underlying the pumping action of the heart is mediated by the process of excitation-contraction coupling (ECC). While triggered by Ca 2+ entry across the sarcolemma during the action potential, it is the release of Ca 2+
Demydenko, Kateryna, Ekhteraei-Tousi, Samaneh, Roderick, H. Llewelyn   +2 more
openaire   +4 more sources

Are there subtypes of the inositol 1,4,5-trisphosphate receptor? [PDF]

Biochemical Journal, 1990
We have compared the properties of the [3H]Ins(1,4,5)P3-binding sites from a number of tissues in an attempt to determine if heterogeneity exists within the Ins(1,4,5)P3-receptor family. The binding of Ins(1,4,5)P3 was characterized in detail by using membranes prepared from human uterine smooth muscle and bovine adrenal cortex.
M A, Varney, J, Rivera, A, Lopez Bernal, S P, Watson   +3 more
openaire   +2 more sources

Mitochondrial respiration and Ca2+ waves are linked during fertilization and meiosis completion [PDF]

, 2003
Fertilization increases both cytosolic Ca(2+) concentration and oxygen consumption in the egg but the relationship between these two phenomena remains largely obscure.
Smith, Peter J., Cibert, Christian, Porterfield, Marshall, Rouviere, Christian, Sardet, Christian, Hammar, Katherine, Porterfield, D. Marshall, Smith, Peter J. S., Dumollard, Remi, Hammar, Katherine M.   +9 more
core   +1 more source

Porcine Circovirus Type 2 Activates CaMMKβ to Initiate Autophagy in PK-15 Cells by Increasing Cytosolic Calcium

Viruses, 2016
Porcine circovirus type 2 (PCV2) induces autophagy via the 5′ adenosine monophosphate-activated protein kinase (AMPK)/extracellular signal-regulated kinase (ERK)/tuberous sclerosis complex 2 (TSC2)/mammalian target of rapamycin (mTOR) pathway in pig ...
Yuanxing Gu, Baozhu Qi, Yingshan Zhou, Xiaowu Jiang, Xian Zhang, Xiaoliang Li, Weihuan Fang   +6 more
doaj   +1 more source

Inositol 1,4,5-Trisphosphate and Calcium Regulate the Calcium Channel Function of the Hepatic Inositol 1,4,5-Trisphosphate Receptor [PDF]

Journal of Biological Chemistry, 1997
The regulation of the inositol 1,4,5-trisphosphate (IP3) receptor in liver was analyzed using a novel superfusion method. Hepatic microsomes were loaded with 45Ca2+, and superfused at high flow rates to provide precise control over IP3 and Ca2+ concentrations ([Ca2+]) and to isolate 45Ca2+ release from reuptake.
J F, Dufour, I M, Arias, T J, Turner
openaire   +2 more sources

MiR-135a-5p Is Critical for Exercise-Induced Adult Neurogenesis

Stem Cell Reports, 2019
Summary: Physical exercise stimulates adult hippocampal neurogenesis and is considered a relevant strategy for preventing age-related cognitive decline in humans. The underlying mechanisms remains controversial.
Meritxell Pons-Espinal, Caterina Gasperini, Matteo J. Marzi, Clarissa Braccia, Andrea Armirotti, Alexandra Pötzsch, Tara L. Walker, Klaus Fabel, Francesco Nicassio, Gerd Kempermann, Davide De Pietri Tonelli   +10 more
doaj   +1 more source

The Clustering of Inositol 1,4,5-Trisphosphate (IP3) Receptors Is Triggered by IP3 Binding and Facilitated by Depletion of the Ca2+ Store

Journal of Pharmacological Sciences, 2008
The inositol 1,4,5-trisphosphate receptors (IP3Rs) form clusters following agonist stimulation, but its mechanism remains controversial. In this study, we visualized the clustering of green fluorescent protein (GFP)-tagged type 3 IP3R (GFP-IP3R3) in ...
Yosuke Tojyo, Takao Morita, Akihiro Nezu, Akihiko Tanimura   +3 more
doaj   +1 more source

Muscarinic acetylcholine receptor-dependent and NMDA receptor-dependent LTP and LTD share the common AMPAR trafficking pathway

iScience, 2023
Summary: The forebrain cholinergic system promotes higher brain function in part by signaling through the M1 muscarinic acetylcholine receptor (mAChR). Long-term potentiation (LTP) and long-term depression (LTD) of excitatory synaptic transmission in the
Tomonari Sumi, Kouji Harada
doaj   +1 more source

Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity [PDF]

, 2012
Synaptic long-term potentiation (LTP) at spinal neurons directly communicating pain-specific inputs from the periphery to the brain has been proposed to serve as a trigger for pain hypersensitivity in pathological states.
Todd, A. J., Martina Kurejova, Thomas Kuner, Irmgard Tegeder (179372), Hu, S.J., Kurejova Martina, Bali, K.K., Agarwal, Nitin, Anke Tappe-Theodor, Bali, Kiran Kumar, Polgar Erika, Franz Hofmann (179398), Todd, A.J., Lewin, G., Kuner Thomas, Ceng Luo (179354), Feil, Robert, Jens Schlossmann, Polgar, E., Gangadharan Vijayan, Andrew J Todd, Kurejova, Martina, Feil, Susanne, Ceng Luo, Hu, S., Susanne Feil (179376), Andrew J. Todd (179384), Feil, R., Rohini Kuner (179428), Erika Polgar (5649442), Rohini Kuner, Hu, San-Jue, Liu Da-Lu, Liu, D., Kuner, Thomas, San-Jue Hu (179417), Feil, S., Tegeder, Irmgard, Tappe-Theodor Anke, Kuner, R., Nitin Agarwal (179363), Robert Feil (28669), Agarwal, N., Agarwal Nitin, Xie, R.G., Robert Feil, Kiran Kumar Bali (179358), Da-Lu Liu (179408), Erika Polgar, Kuner, T., Tappe, Anke, Gary Lewin (179380), Liu, Da-Lu, Xie, R. G., Jens Schlossmann (179389), Nitin Agarwal, Luo, Ceng, Luo, C., Vijayan Gangadharan, Hu, S. J., Xie, Rou-Gang, Hofmann Franz, Da-Lu Liu, Rou-Gang Xie (179362), Bali Kiran Kumar, Tappe-Theodor, A., Kuner, Rohini, Lewin Gary, Liu, D. L., Kiran Kumar Bali, Irmgard Tegeder, Polgár, Erika, Hofmann, Franz, Tegeder Irmgard, Vijayan Gangadharan (179356), Rou-Gang Xie, Schlossmann Jens, Franz Hofmann, Feil Susanne, Hu San-Jue, San-Jue Hu, Xie Rou-Gang, Gangadharan, Vijayan, Todd Andrew J., Feil Robert, Martina Kurejova (179365), Bali, K. K., Gary Lewin, Susanne Feil, Anke Tappe-Theodor (179367), Lewin, Gary R., Schlossmann, Jens, Liu, D.L., Thomas Kuner (162293), Schlossmann, J., Luo Ceng, Gangadharan, V., Hofmann, F., Kuner Rohini, Todd, Andrew J., Xie, R., Tegeder, I., Kurejova, M., Luo, C;Gangadharan, V;Bali, KK;Xie, RG;Agarwal, N;Kurejova, M;Tappe-Theodor, A;Tegeder, I;Feil, S;Lewin, G;Polgar, E;Todd, AJ;Schlossmann, J;Hofmann, F;Liu, DL;Hu, SJ;Feil, R;Kuner, T;Kuner, R   +103 more
core   +2 more sources

Mechanism and function of drosophila capa GPCR: a desiccation stress-responsive receptor with functional homology to human neuromedinU receptor [PDF]

, 2012
The capa peptide receptor, capaR (CG14575), is a G-protein coupled receptor (GPCR) for the D. melanogaster capa neuropeptides, Drm-capa-1 and -2 (capa-1 and -2). To date, the capa peptide family constitutes the only known nitridergic peptides in insects,
Julian A. T. Dow, Davies Shireen-A., Selim Terhzaz (173629), Pablo Cabrero (189088), Jonathan C Radford, Shireen-A Davies, Robben Joris H., Cabrero Pablo, Brian D Hudson, Terhzaz Selim, Brian D. Hudson (189093), Joris H. Robben (189090), Graeme Milligan (76078), Cabrero, P., Hudson, B.D., Pablo Cabrero, Shireen-A. Davies, Hudson Brian D., Graeme Milligan, Jonathan C. Radford, Robben, J.H., Selim Terhzaz, Milligan Graeme, Joris H. Robben, Dow, J.A., Dow, J.A.T., Shireen-A. Davies (189097), Brian D. Hudson, Julian A T Dow, Radford, J.C., Joris H Robben, Jonathan C. Radford (189091), Terhzaz, S., Dow Julian A. T., Julian A. T. Dow (173652), Radford Jonathan C., Milligan, G., Davies, S.A.   +37 more
core   +2 more sources