Results 101 to 110 of about 58,268 (235)

Hormone-Induced Calcium Oscillations Depend on Cross-Coupling with Inositol 1,4,5-Trisphosphate Oscillations

Cell Reports, 2014
Receptor-mediated oscillations in cytosolic Ca2+ concentration ([Ca2+]i) could originate either directly from an autonomous Ca2+ feedback oscillator at the inositol 1,4,5-trisphosphate (IP3) receptor or as a secondary consequence of IP3 oscillations ...
Lawrence D. Gaspers, Paula J. Bartlett, Antonio Politi, Paul Burnett, Walson Metzger, Jane Johnston, Suresh K. Joseph, Thomas Höfer, Andrew P. Thomas   +8 more
doaj   +1 more source

Inositol 1,4,5-Trisphosphate Receptor Type 3 Regulates Neuronal Growth Cone Sensitivity to Guidance Signals

iScience, 2020
Summary: During neurodevelopment, the growth cone deciphers directional information from extracellular guidance cues presented as shallow concentration gradients via signal amplification.
Carmen Chan, Noriko Ooashi, Hiroki Akiyama, Tetsuko Fukuda, Mariko Inoue, Toru Matsu-ura, Tomomi Shimogori, Katsuhiko Mikoshiba, Hiroyuki Kamiguchi   +8 more
doaj   +1 more source

Mobilization of Intracellular Calcium by Methacholine and Inositol 1,4,5-Trisphosphate in Rat Parotid Acinar Cells

, 1987
In the rat parotid acinar cell, methacholine caused an increase in [Ca2+]i as determined by quin-2 fluorescence. The increase in [Ca2+] i was initially independent of, and subsequently dependent on, the presence of extracellular Ca2+, indicating ...
J.W. Putney, D.L. Aub
core   +1 more source

Developmental and Regional Studies of the Metabolism of Inositol 1,4,5-Trisphosphate in Rat Brain [PDF]

, 1990
Coupling of CNS receptors to phosphoinositide turnover has previously been found to vary with both age and brain region. To determine whether the metabolism of the second messenger inositol 1,4,5-trisphosphate also displays such variations, activities of
Seguin, Edward B., Heacock, Anne M., Agranoff, Bernard W.   +2 more
core   +1 more source

ORGN 684-Synthesis and biological action of novel 4-position-modified derivatives of D-myo-inositol 1,4,5-trisphosphate [PDF]

, 2007
The design of a range of 4-position-modified D-myo-inositol 1,4,5-trisphosphate derivatives is described. The enantioselective synthesis of these compounds is reported, along with initial biological analysis, which indicates that these compounds do not ...
Conway, Stuart John, Bultynck, G, Roderick, H. L.Lewelyn, Aslam, Tashfeen, Bultynck, Geert, Roderick, H. Llewellyn, Conway, Stuart J., Slawin, Alexandra M Z, Roderick, H L, Roderick, H. Llewelyn, Bootman, MD, Slawin, AM, Bello, Davide, Bootman, M D, Roderick, HL, Aslam, Tashfeen; id_orcid, Conway, Stuart, Slawin, Alexandra Martha Zoya, Slawin, Alexandra M.Z., Bello, D, Aslam, T, Conway, SJ, Slawin, A M Z, Slawin, AMZ, Bootman, Martin D., Slawin, Alexandra M. Z.   +25 more
core   +1 more source

Insights Into Aggregation‐Delayed Phenotype of Dictyostelium discoideum

Cell Biology International, Volume 50, Issue 9, September 2026.
ABSTRACT Dictyostelium discoideum is a cellular model that has been widely used in cell signal research focusing on different cellular and developmental processes. The unique lifecycle of these cells—which involves switching between vegetative and development phases—makes Dictyostelium a reliable model for investigations in this field.
Sarah Abdulaziz Alamer
wiley   +1 more source

Enriched endoplasmic reticulum-mitochondria interactions result in mitochondrial dysfunction and apoptosis in oocytes from obese mice

Journal of Animal Science and Biotechnology, 2017
Background Maternal obesity alters oocytes and subsequent fetal metabolism. An increasing number of studies have shown that the endoplasmic reticulums (ER) or mitochondria have important effects on oocyte quality, but there has been no study of the ...
Lihong Zhao, Tengfei Lu, Lei Gao, Xiangwei Fu, Shien Zhu, Yunpeng Hou   +5 more
doaj   +1 more source

SHIP1 Restrains Hypoxia/Reoxygenation‐Induced Cytokine Secretion in Mouse Bone Marrow–Derived Mast Cells

European Journal of Immunology, Volume 56, Issue 9, September 2026.
(A) BMMCs are substantially more resistant to oxygen deprivation than neurons, microglia, oligodendrocytes, astrocytes, and fibroblasts. (B) Role of SHIP‐1 in primary mouse bone marrow mast cells’ hypoxia response. Under hypoxia, SHIP‐1 induces cytokine release. SHIP1 restrains hypoxia/reoxygenation‐induced cytokine secretion in BMMCs via the RAS/ RAF,
Lara Gubeljak, Jonas Pes, Eren Arik, Aaron T. Fehr, Mara Schietinger, Thomas Wilhelm, Sandro Capellman, Michael Huber, Pardes Habib   +8 more
wiley   +1 more source

of Inositol 1,4,5-trisphosphate receptor type 1 autoantibodies in paraneoplastic and non-paraneoplastic peripheral neuropathy

, 2016
of Inositol 1,4,5-trisphosphate receptor type 1 autoantibodies in paraneoplastic and non-paraneoplastic peripheral ...
Klaus-Peter Wandinger (316413), Lars Komorowski (3435767), Eva Neuen-Jacob (3435770), Sven Jarius (25658), JĂźrgen Haas (7540967), Kai Fechner (3435773), Harald Hefter (298300), Andreas Moser (412683), Orhan Aktas (25659), Marius Ringelstein (171207), Hans-Peter Hartung (112650), Philipp Albrecht (171205), Irina Serysheva (3435764), Brigitte Wildemann (316416)   +13 more
core   +1 more source

miR‐132 loss de‐represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain

EMBO Molecular Medicine, 2016
microRNA‐132 (miR‐132) is involved in prosurvival, anti‐inflammatory and memory‐promoting functions in the nervous system and has been found consistently downregulated in Alzheimer's disease (AD).
Evgenia Salta, Annerieke Sierksma, Elke Vanden Eynden, Bart De Strooper   +3 more
doaj   +1 more source