Results 201 to 210 of about 761,638 (295)
Effect of exogenous phytase on degradation of inositol phosphate in dairy cows.
Journal of Dairy Science, 2013 D. Brask-Pedersen +4 more
semanticscholar +1 more source
MicrobiologyOpen, Volume 15, Issue 1, February 2026.This study demonstrates that the BvrR induces neuroinflammation. In microglial cells, BvrR expression localizes to the endoplasmic reticulum (ER), causing ER expansion and activating the stress sensor IRE1. Phosphorylated IRE1 subsequently drives the activation and nuclear translocation of transcription factors ATF2 and NF‐κB p65.
Zhao Wang +3 more
wiley +1 more source
MedComm, Volume 7, Issue 2, February 2026.Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao +8 more
wiley +1 more source
Deceptive beauty of non‐natural structures
Protein Science, Volume 35, Issue 2, February 2026.Abstract Structures of proteins and multiprotein complexes are considered landmark achievements. However, in many cases, mutant proteins are used for structural work. Even when wild type proteins are used, crystallization or complex formation for cryoEM is performed in highly nonphysiological conditions.
Vsevolod V. Gurevich +1 more
wiley +1 more source
Advances in Therapeutic Antibody Discovery and Development Targeting G Protein‐Coupled Receptors
Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.ABSTRACT G protein‐coupled receptors (GPCRs) are integral to numerous biological processes and are associated with various diseases across all therapeutic areas. Consequently, GPCRs present substantial potential for antibody‐based therapies. This review offers an overview of the therapeutic GPCR‐antibody target landscape and examines the diversity ...
Catherine J. Hutchings +6 more
wiley +1 more source
Lifespan‐Extending Endogenous Metabolites
Aging Cell, Volume 25, Issue 2, February 2026.Endogenous metabolites act as mediators of longevity by modulating conserved cellular pathways. We summarize mechanistic evidence linking specific metabolites to lifespan and healthspan benefits across model systems, with discussion of clinical evidence, translational opportunities, and remaining knowledge gaps.
Yizhou Jiang, Jing‐Dong J. Han
wiley +1 more source
Isoproterenol modulates insulin activation of insulin receptor kinase in intact rat adipocytes [PDF]
, 1988 Klein, H. H. +2 more
core
Advanced Healthcare Materials, Volume 15, Issue 4, 26 January 2026.Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentralized monitoring, using alternative body biofluids.
Lanka Tata Rao +2 more
wiley +1 more source
Advanced Materials, Volume 38, Issue 3, 13 January 2026.This study introduces glutathione‐stabilized gold nanoparticles for targeted lithium delivery (LiG‐AuNPs), enabling the controlled modulation of Glycogen Synthase Kinase‐3 (GSK‐3β). These non‐toxic, 2‐nm particles release lithium intracellularly, effectively inhibiting GSK‐3β in the brain without significant plasma lithium alterations.
Antonio Buonerba +20 more
wiley +1 more source
Advanced Science, Volume 13, Issue 1, 5 January 2026.Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin +14 more
wiley +1 more source