Results 211 to 220 of about 494,776 (288)
Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood +7 more
wiley +1 more source
From wild to tamed: Reimagining novel crops through omics and local plant diversity
The global food system faces growing pressure from climate change, biodiversity loss, and rising nutritional demands. Agriculture has increased yields but reduced crop diversity, flavor, and nutritional quality, leaving societies vulnerable and dependent on a narrow set of staple species.
Alexandra Sanfeliu Meliá +1 more
wiley +1 more source
ABSTRACT Background Ulcerative colitis (UC) is a challenging inflammatory bowel disease characterized by chronic inflammation of the colon's mucosal layer. Despite advances in medical research, UC lacks definitive diagnostic tests and targeted treatments.
Shuai Wang, Hualiang Deng, Dajuan Sun
wiley +1 more source
Harnessing <sup>13</sup>C-labeled <i>myo</i>-inositol to interrogate inositol phosphate messengers by NMR. [PDF]
Harmel RK +5 more
europepmc +1 more source
Stoichiometric Binding of Cyclophilin‐A to The HIV‐1 Capsid Modulates Its Mechanoelastic Properties
The HIV‐1 capsid is a protein nanocapsule that must balance rigidity and flexibility to enter the cell nucleus. Atomic force microscopy simulations reveal that binding of the host protein Cyclophilin A tunes this mechanical response: partial coverage preserves deformability, while excessive binding induces brittleness and failure.
Juan S. Rey +2 more
wiley +1 more source
ABSTRACT Rhinacanthus nasutus (L.) Kurz is a medicinal plant whose roots, stems, and leaves are commonly used in tea and traditional Chinese medicine; however, the beneficial effects of its flowers remain to be investigated. In this study, the lactic acid bacteria (LAB) found in the flowers of R.
Fumie Niitsuma +6 more
wiley +1 more source
YlYxc1, an ER‐associated alkaline ceramidase of Yarrowia lipolytica, has the hydrolytic activity of ceramides, which can be exploited as a metabolic engineering target to enhance long‐chain base production. ABSTRACT Long‐chain bases (LCBs; sphingoid bases), derived from ceramide metabolism, are valuable sphingolipid intermediates for industrial ...
Seo Hyeon Shin +7 more
wiley +1 more source
ABSTRACT The precise enhancement of nutritional quality in silage maize is a core strategy for increasing livestock production efficiency. Through evolutionary analysis of multiple plant species, we identified two functionally synergistic upstream open reading frames (uORF1 and uORF2) within the 5′ untranslated region of the gene encoding GDP‐L ...
Jing Zhou +13 more
wiley +1 more source
ABSTRACT Breeding crops with robust disease resistance often compromises yield, a persistent challenge in agricultural improvement. We report that modifying cell wall architecture through a xylan‐specific glycosyltransferase successfully breaks this trade‐off in wheat.
Shufang Sun +6 more
wiley +1 more source

