Results 211 to 220 of about 71,946 (261)
Some of the next articles are maybe not open access.
Inositol phosphates and cell signalling
Nature, 1989Inositol 1,4,5-trisphosphate is a second messenger which regulates intracellular calcium both by mobilizing calcium from internal stores and, perhaps indirectly, by stimulating calcium entry. In these actions it may function with its phosphorylated metabolite, inositol 1,3,4,5-tetrakisphosphate. The subtlety of calcium regulation by inositol phosphates
M J, Berridge, R F, Irvine
openaire +2 more sources
Mass measurement of inositol phosphates
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1989This review summarises the methods available for the mass measurement of inositol phosphates, i.e., use of radioactive inositol lipid precursors, optical techniques, gas chromatography, mass spectrometry, nuclear magnetic resonance, fast atom bombardment and assays specific for Ins(1,4,5)P3.
Palmer, S, Wakelam, M J
openaire +4 more sources
Paosphorothioate Analogues of Inositol Phosphates
Phosphorus, Sulfur, and Silicon and the Related Elements, 1990Abstract Novel analogues of the intracellular second messenger D-myo-inositol 1,4,5-trisphosphate, which possess phosphorothioate groups in place of phosphate groups have been synthesized. They exhibit unusual biological properties which will be of considerable application in understanding the phosphoinositide cycle.
Allan Cooke +3 more
openaire +1 more source
Methods for the analysis of inositol phosphates
Analytical Biochemistry, 1989Interest in the inositol phospholipids was stimulated by the simultaneous discoveries that the products of hydrolysis of these lipids could serve as messengers to activate to synergistic signaling pathways in hormonally responsive cells, namely, inositol 1,4,5-trisphosphate which causes the release of Ca2+ from intracellular stores and diacylglycerol ...
N M, Dean, M A, Beaven
openaire +2 more sources
A bioautographic method for the identification of inositol and inositol phosphate
Analytical Biochemistry, 1962Abstract A bioautographic method, utilizing Saccharomyces carlsbergensis strain 4228, was shown to be capable of detecting and distinguishing between myoinositol, myoinositol 2-phosphate, and other derivatives of myoinositol. The method was shown to respond to as little as 1 μg inositol and is effective even in the presence of lipid hydrolyzates.
openaire +2 more sources
Inositol Phosphates in the Nucleus
Science, 2000The inositol signaling pathways in the cytoplasm are well characterized. In a Perspective, Chi and Crabtree now explain how similar inositol pathways operate in the nucleus to switch gene expression on and off. One of the key players is the kinase Ipk2p, which might stabilize components of a transcription complex ( Odom et al.).
Tian H. Chi, Gerald R. Crabtree
openaire +1 more source
Inositol Phosphates and Their Metabolism in Plants
1996The discovery that plasma membrane phosphoinositides mediate cellular responses to external signals has led to tremendous interest in the structure and metabolism of phosphoinositides and inositol phosphates. The role of inositol1,4,5-trisphosphate [Ins(1,4,5)P3] as a mediator of receptor-initiated changes in intracellular calcium is well characterized
openaire +2 more sources
Selective recognition of inositol phosphates by subtypes of the inositol trisphosphate receptor
Biochemical Journal, 2001Synthetic analogues of inositol trisphosphate (IP3), all of which included structures equivalent to the 4,5-bisphosphate of (1,4,5)IP3, were used to probe the recognition properties of rat full-length type 1, 2 and 3 IP3 receptors expressed in insect Spodoptera frugiperda 9 cells.
E P, Nerou +3 more
openaire +2 more sources
Formation and Metabolism of Inositol Phosphates: The Inositol Tris/Tetrakisphosphate Pathway
1988Many cell functions are modulated by receptor-activated mechanisms that act by increasing the free Ca2+ concentration in the cytosol (Williamson et al, 1981; Rasmussen and Barrett, 1984). Calcium mediates its effects by causing activity changes of a variety of proteins, including protein kinases, either directly or after binding to calmodulin or other ...
J R, Williamson +4 more
openaire +2 more sources