Results 201 to 210 of about 30,835 (333)

Genetic variants underlying precancerous conditions of hepatocellular carcinoma

International Journal of Cancer, Volume 158, Issue 3, Page 488-502, 1 February 2026.
Abstract Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for 80% of cases worldwide. While chronic hepatitis B and C infections remain primary risk factors, emerging evidence highlights the increasing contributions of metabolic dysfunction‐associated steatotic liver disease (MASLD) and alcohol‐associated liver disease
Jonathan Jaime G. Guerrero, Paolo C. Encarnacion, Mark Angelo S. del Rosario, Matthew Aldren S. Ora, Jiayan Zhou, Kin Israel Notarte, Wan‐Chun Li, Ching‐Wen Chang   +7 more
wiley   +1 more source

Establishing ¹⁸O-Labeled Inositol Phosphates for Quantitative Capillary Electrophoresis-Mass Spectrometry: Fragmentation Pathways and Comparison with ¹³C-Labeled Analogs. [PDF]

Anal Chem
Liu G, Dürr-Mayer T, Lu M, Jessen HJ.
europepmc   +1 more source

Multi‐Omics Revealed the Effects of Intrauterine Hyperglycemia Exposure on the Development of Skeletal Muscle in Offspring

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Gestational diabetes mellitus (GDM), a common pregnancy complication characterized by maternal hyperglycemia, negatively impacts offspring health. Skeletal muscle, a critical tissue for glucose and lipid metabolism, is especially vulnerable to prenatal environmental insults.
Rui Liu, Junsen She, Xinyuan Li, Yishang Yan, Jiaying Mo, Jianzhong Sheng, Hongbo Yang, Hefeng Huang   +7 more
wiley   +1 more source

Inositol phosphates dynamically enhance stability, solubility, and catalytic activity of mTOR. [PDF]

J Biol Chem
Rameh LE, York JD, Blind RD.
europepmc   +1 more source

Distinct Metabolomic Alterations Are Associated With Physical Function, Weight Loss, and Muscle Mass in Men With Cancer

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Treatments for cancer cachexia, defined as involuntary weight and muscle mass loss leading to significant functional impairment, remain unavailable partly due to insufficient improvement of clinically meaningful outcomes in current trials.
Lindsey J. Anderson, Lu Xia, Haiming Kerr, Marin Cabrera, Fabien Chu, Jaqueline Rose, Peter C. Wu, Atreya Dash, Sina A. Gharib, Jose M. Garcia   +9 more
wiley   +1 more source

ITPK1 mediates the lipid-independent synthesis of inositol phosphates controlled by metabolism. [PDF]

Proc Natl Acad Sci U S A, 2019
Desfougères Y, Wilson MSC, Laha D, Miller GJ, Saiardi A.   +4 more
europepmc   +1 more source

Climate change and the antinutrient–antioxidant puzzle in common bean seeds

Journal of the Science of Food and Agriculture, Volume 106, Issue 3, Page 1451-1456, February 2026.
Abstract Non‐proteinaceous and proteinaceous antinutrients in common bean (Phaseolus vulgaris L.) seeds can negatively affect human nutrition by reducing mineral bioavailability and impairing protein digestibility during digestion, respectively. However, many of these compounds also possess strong antioxidant properties that can help protect the plant ...
Juan Vorster, Eleonora Cominelli, Francesca Sparvoli, Alessia Losa, Tea Sala, Karl Kunert   +5 more
wiley   +1 more source

Actions of inositol phosphates on Ca2+ pools in guinea-pig hepatocytes [PDF]

, 1984
Gillian M. Burgess, Robin F. Irvine, M J Berridge, Jerry S. McKinney, James W. Putney   +4 more
openalex   +1 more source

BvrR From Brucella abortus Induces Neuroinflammation Through IRE1‐Mediated Activation of ATF2 and NF‐κB

MicrobiologyOpen, Volume 15, Issue 1, February 2026.
This study demonstrates that the BvrR induces neuroinflammation. In microglial cells, BvrR expression localizes to the endoplasmic reticulum (ER), causing ER expansion and activating the stress sensor IRE1. Phosphorylated IRE1 subsequently drives the activation and nuclear translocation of transcription factors ATF2 and NF‐κB p65.
Zhao Wang, Xinwen Yu, Boyu Liu, Dongni Ren   +3 more
wiley   +1 more source

Sequence-based identification of inositol monophosphatase-like histidinol-phosphate phosphatases (HisN) in Corynebacterium glutamicum, Actinobacteria, and beyond [PDF]

, 2017
Robert Kulis-Horn, Christian Rückert, Jörn Kalinowski, Marcus Persicke   +3 more
openalex   +1 more source