Results 181 to 190 of about 27,445 (272)
Transcriptome assemblies for two drug‐type cannabis chemotypes by long‐read RNA sequencing
The Plant Genome, Volume 19, Issue 2, June 2026.Abstract Cannabis sativa has undergone over 10,000 years of domestication, resulting in extensive genetic and phenotypic diversity among cultivated chemotypes. Increased medical and recreational use of specialized metabolites accumulating in cannabis glandular trichomes—primarily the cannabinoids ∆9‐tetrahydrocannabinol (THC) and cannabidiol (CBD)—has ...
Oliver Berkowitz +5 more
wiley +1 more source
Establishing <sup>18</sup>O-Labeled Inositol Phosphates for Quantitative Capillary Electrophoresis-Mass Spectrometry: Fragmentation Pathways and Comparison with <sup>13</sup>C-Labeled Analogs. [PDF]
Anal ChemLiu G, Dürr-Mayer T, Lu M, Jessen HJ.
europepmc +1 more source
GRKs and arrestins: Nomenclature and functions in GPCR‐dependent and ‐independent signalling
British Journal of Pharmacology, Volume 183, Issue 11, Page 2619-2633, June 2026.G protein‐coupled receptor (GPCR) kinases (GRKs) and arrestins play a critical role in the regulation of GPCR signalling. Historic names of mammalian GRKs were replaced by systematic ones in the 1990s; however, both kinds of names are currently in use for mammalian arrestins.
Vsevolod V. Gurevich
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, Volume 20, Issue 5, Page 1347-1363, May 2026.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
FEBS Open Bio, Volume 16, Issue 5, Page 906-920, May 2026.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source
Isoproterenol modulates insulin activation of insulin receptor kinase in intact rat adipocytes [PDF]
, 1988 Klein, H. H. +2 more
core
Advanced Science, Volume 13, Issue 26, 8 May 2026.ABSTRACT Inositol pyrophosphates (PP‐InsPs) are central regulators of eukaryotic signaling events. While certain PP‐InsP isomers have been conclusively linked to the regulation of phosphate homeostasis through interaction with SPX domain‐containing proteins in plants, the functions of the recently discovered isomer 4/6‐PP‐InsP5 remain largely unknown ...
Kevin Ritter +10 more
wiley +1 more source
Inositol phosphates are assembly co-factors for HIV-1. [PDF]
Nature, 2018 Dick RA +11 more
europepmc +1 more source
Engineering a Synthetic Formatotrophic Yeast With Enhanced Growth Capacity on Formate
Advanced Energy and Sustainability Research, Volume 7, Issue 5, May 2026.Engineering Yeast for Growth on Formate and Methanol via Serine‐Centered C1 Coupling. By engineering serine metabolism and remodeling the rGly pathway, we rendered yeast growth strictly dependent on formate. This synthetic formatotrophy enables growth on dual‐C1 substrates by channeling formate into the central metabolism via serine deaminases and ...
Shuyuan Guo +11 more
wiley +1 more source