Results 201 to 210 of about 84,951 (279)

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

Global Proteomic Analysis of Sperm and Seminal Plasma From Tropically‐Adapted Rams With Contrasting Parameters of Frozen‐Thawed Semen

Molecular Reproduction and Development, Volume 93, Issue 10, October 2026.
ABSTRACT The aim of this study was to characterize the proteome of sperm and seminal plasma (SP) from rams with high semen freezability (HF) and low semen freezability (LF). Eleven ejaculates were collected from 12 rams, at 3‐day intervals, and cryopreserved (132 semen samples).
Wallisson Bruno de Morais Pacheco, Iran Aguila Maciel, Suane Santos Alves dos Santos, Alan Martins de Araújo, Francisca Nágila Matos Almeida, Denise Damasceno Guerreiro, Sheheryar Sheheryar, Lais Lacerda Brasil de Oliveira, Felipe Domingos de Sousa, Mohibullah Shah, Maria Elisabete Amaral Moraes, Carlos Roberto Koscky Paier, Ana Cristina de Oliveira Monteiro, Carminda Sandra Brito Salmito‐Vanderley, Arlindo A. Moura   +14 more
wiley   +1 more source

1H HR‐MAS NMR Metabolomics in Combination With Transcriptomic Correlation Provides New Insights Into Metabolic Heterogeneity Across Breast Cancer Immunohistochemical Subtypes

NMR in Biomedicine, Volume 39, Issue 10, October 2026.
Metabolomic profiling of breast cancer tissue using 1H HR‐MAS NMR spectroscopy and LCModel‐based quantitative analysis revealed metabolite differences associated with immunohistochemical subtypes, and subsequent metabolomics–transcriptomics integration linked these subtype‐dependent metabolic signatures to pathways in choline metabolism, one‐carbon ...
Irene Garcia‐Bocanegra, Jesus David Urbano‐Gamez, Antonio Perez‐Cardona, Laura Barrios, Maria Isabel Somoza‐Ramírez, Luis Vicioso, Elena Pardo‐Susacasa, Gema Diaz‐Cordoba, Maria Mercedes Acebal‐Blanco, Francisco Sendra‐Portero, Maria Luisa Garcia‐Martin   +10 more
wiley   +1 more source

Ginsenoside Rg3 Promotes Healthy Aging Through Phosphoinositide‐Associated Lysosomal Regulation in Caenorhabditis elegans

Aging Cell, Volume 25, Issue 10, October 2026.
Ginsenoside Rg3 shifts neuronal phosphoinositide reporter signatures toward increased PI(4)P and reduced PI(3)P signals. These changes are coupled to TORC1 suppression and HLH‐30/TFEB activation, alongside restored autophagic flux and lysosomal competence, preserved neuronal proteostasis, and extended lifespan in Caenorhabditis elegans.
Haiyang Yu, Shiming Li, Yongsheng Chen, Yaoyong Zeng, Junbu Li, Yuxin Guo, Wanxiang Zhang, Lizhu Zhang, Longnong You, Kuncan Chen, Jinhong Wu, Dan Gan, Jiane‐Kang Liu, Lingjun Zheng   +13 more
wiley   +1 more source

Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies. [PDF]

Adv Sci (Weinh)
Saiardi A, Lu M, Zhang Y, Shukla A, Ko AA, Jessen HJ.   +5 more
europepmc   +1 more source

The Crosstalk Between Diabetes and Alzheimer's Disease: A Molecular Perspective

Basic &Clinical Pharmacology &Toxicology, Volume 139, Issue 4, October 2026.
Increasing evidence indicates an association between type 2 diabetes mellitus and Alzheimer’s disease, contributing to the proposed concept of AD as “type 3 diabetes.” Shared biological features such as impaired insulin signaling, chronic inflammation, mitochondrial dysfunction, and oxidative stress have been observed in both T2DM and AD.
Deniz Catakli, Ozlem Ozen‐Basoglu, Ebru Busra Tuncgovde, Gonen Ozsarlak‐Sozer   +3 more
wiley   +1 more source

Pools of independently cycling inositol phosphates revealed by pulse labeling with ¹⁸ O-water

Kim G, Liu G, Qiu D, Gopaldass N, De Leo G, Hermes J, Timmer J, Saiardi A, Mayer A, Jessen H.   +9 more
europepmc   +1 more source

Dualsteric and dual‐acting modulation of muscarinic receptors by antagonist KH‐5

British Journal of Pharmacology, Volume 183, Issue 19, Page 5769-5790, October 2026.
Abstract Background and purpose Muscarinic acetylcholine receptors are key therapeutic targets, and ligands engaging both orthosteric and allosteric sites may offer improved selectivity and efficacy. Here, we investigated whether the muscarinic antagonist KH‐5 acts as a dualsteric antagonist and defined its mode of interaction with muscarinic receptors.
Alena Janoušková‐Randáková, Eva Dolejší, Nikolai Chetverikov, Jan Jakubík   +3 more
wiley   +1 more source

Compounding Impacts—Genomic Exploration of the Potential Effect of Domestic Introgression on Climate Adaptation in Atlantic Salmon (Salmo salar)

Evolutionary Applications, Volume 19, Issue 10, October 2026.
ABSTRACT Predicting population, species, and community responses to climate change is critical for the successful management of wild ecosystems. However, climate change does not act alone. Interactions among climate change and other anthropogenic threats could significantly complicate predictions of global change yet have rarely been examined.
Hallie Arno, Tony Kess, Steve Duffy, Benjamin Marquis, Samantha V. Beck, Sarah J. Lehnert, Ian A. Fleming, Ian R. Bradbury   +7 more
wiley   +1 more source

Mechanisms and Research Progress of Phosphate-Solubilizing Microorganisms in Promoting Sustainable Crop Production. [PDF]

Microorganisms
Wang J, Yu X, Dong P, Li Y, Zhang Y, Wang G.   +5 more
europepmc   +1 more source