Cellular IP6 Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP6 Are Attenuated for Infection and Replication [PDF]
Cell Reports, 2019 Summary: HIV-1 hijacks host proteins to promote infection. Here we show that HIV is also dependent upon the host metabolite inositol hexakisphosphate (IP6) for viral production and primary cell replication.
Donna L Mallery +2 more
exaly +8 more sources
Influence of pH on the cytotoxic activity of inositol hexakisphosphate (IP6) in prostate cancer [PDF]
Frontiers in Oncology, 2011 Objectives: In the present study, we investigated whether the pH of IP6 could influence its anti-tumoral activity in vitro. Methods: PC-3 cells were exposed to IP6 at pH 5, pH 7 and pH 12 and we evaluated the metabolic activity (WST-1 assay), cell ...
Philippe O Gannon +2 more
exaly +5 more sources
Essential functions of inositol hexakisphosphate (IP6) in murine leukemia virus replication
MBioWe have investigated the function of inositol hexakisphosphate (IP6) and inositol pentakisphosphate (IP5) in the replication of murine leukemia virus (MLV).
Banhi Biswas +2 more
exaly +6 more sources
Structural basis for HIV-1 capsid adaption to a deficiency in IP6 packaging [PDF]
Nature CommunicationsInositol hexakisphosphate (IP6) promotes HIV-1 assembly by stabilizing the immature Gag lattice and becomes enriched within virions, where it is required for mature capsid assembly.
Yanan Zhu +11 more
doaj +4 more sources
A Structural Perspective of the Role of IP6 in Immature and Mature Retroviral Assembly [PDF]
Viruses, 2021 The small cellular molecule inositol hexakisphosphate (IP6) has been known for ~20 years to promote the in vitro assembly of HIV-1 into immature virus-like particles.
Martin Obr +2 more
doaj +3 more sources
Osteoblast and osteoclast responses to chelate-setting calcium phosphate cements with different solubilities [PDF]
Biomaterials and BiosystemsArtificial bone grafts are widely used to treat bone defects, and paste-type materials capable of setting into arbitrary shapes offer particularly high clinical value.
Minami Kosuge +3 more
doaj +2 more sources
Frontiers in Nutrition, 2022 Inositol hexaphosphate (IP6) is a phytochemical widely found in grains and legumes that plays an anti-cancer role. However, the mechanism underlying the inhibition of colorectal cancer metastasis by IP6 through host genes, gut microbiota, and their ...
Tong-Tong Lan +10 more
exaly +3 more sources
Cellular and Molecular Activities of IP6 in Disease Prevention and Therapy
Biomolecules, 2023 IP6 (phytic acid) is a naturally occurring compound in plant seeds and grains. It is a poly-phosphorylated inositol derivative that has been shown to exhibit many biological activities that accrue benefits in health and diseases (cancer, diabetes, renal lithiasis, cardiovascular diseases, etc.). IP6 has been shown to have several cellular and molecular
Felix Omoruyi
exaly +5 more sources
IP6 Regulation of HIV Capsid Assembly, Stability, and Uncoating [PDF]
Viruses, 2018 The mechanisms that drive formation of the HIV capsid, first as an immature particle and then as a mature protein shell, remain incompletely understood. Recent discoveries of positively-charged rings in the immature and mature protein hexamer subunits that comprise them and their binding to the cellular metabolite inositol hexakisphosphate (IP6) have ...
Robert A Dick +2 more
exaly +4 more sources
IP6: From Seeds to Science—A Natural Compound’s Path to Clinical Promise [PDF]
BiomoleculesInositol hexaphosphate (IP6), also known as phytic acid, has historically been classified as an antinutrient due to its mineral-chelating properties, which were believed to impair nutrient absorption.
Alissa Saverino +2 more
doaj +2 more sources