Results 1 to 10 of about 9,735 (211)

Cellular IP6 Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP6 Are Attenuated for Infection and Replication [PDF]

Cell Reports, 2019
Summary: HIV-1 hijacks host proteins to promote infection. Here we show that HIV is also dependent upon the host metabolite inositol hexakisphosphate (IP6) for viral production and primary cell replication.
Donna L Mallery, Alex B Kleinpeter, Miranda Wilson   +2 more
exaly   +13 more sources

Essential functions of inositol hexakisphosphate (IP6) in murine leukemia virus replication

MBio
We have investigated the function of inositol hexakisphosphate (IP6) and inositol pentakisphosphate (IP5) in the replication of murine leukemia virus (MLV).
Banhi Biswas, Kin Kui Lai, Christopher R Aiken   +2 more
exaly   +6 more sources

IP6: From Seeds to Science—A Natural Compound’s Path to Clinical Promise [PDF]

Biomolecules
Inositol hexaphosphate (IP6), also known as phytic acid, has historically been classified as an antinutrient due to its mineral-chelating properties, which were believed to impair nutrient absorption.
Alissa Saverino, AbulKalam M. Shamsuddin, Ivana Vucenik   +2 more
doaj   +3 more sources

Osteoblast and osteoclast responses to chelate-setting calcium phosphate cements with different solubilities [PDF]

Biomaterials and Biosystems
Artificial bone grafts are widely used to treat bone defects, and paste-type materials capable of setting into arbitrary shapes offer particularly high clinical value.
Minami Kosuge, Kyokei Hazama, Kitaru Suzuki, Mamoru Aizawa   +3 more
doaj   +2 more sources

IP6 reduces colorectal cancer metastasis by mediating the interaction of gut microbiota with host genes

Frontiers in Nutrition, 2022
Inositol hexaphosphate (IP6) is a phytochemical widely found in grains and legumes that plays an anti-cancer role. However, the mechanism underlying the inhibition of colorectal cancer metastasis by IP6 through host genes, gut microbiota, and their ...
Tong-Tong Lan, Yang Song, Xiao-Han Liu, Cui-Ping Liu, Hui-Chao Zhao, Yi-Sa Han, Chu-Hui Wang, Ning Yang, Zhen Xu, Meng Tao, Hui Li   +10 more
exaly   +3 more sources

Structure of the mature Rous sarcoma virus lattice reveals a role for IP6 in the formation of the capsid hexamer

Nature Communications, 2021
Inositol hexakisphosphate (IP6) is a known assembly cofactor for HIV-1. Here, the authors show the role of IP6 in the assembly of the Rous sarcoma virus (RSV).
Martin Obr, Clifton L Ricana, Marco Klanschnig   +2 more
exaly   +2 more sources

Structural basis for HIV-1 capsid adaption to a deficiency in IP6 packaging [PDF]

Nature Communications
Inositol hexakisphosphate (IP6) promotes HIV-1 assembly by stabilizing the immature Gag lattice and becomes enriched within virions, where it is required for mature capsid assembly.
Yanan Zhu, Alex B. Kleinpeter, Juan S. Rey, Juan Shen, Yao Shen, Jialu Xu, Nathan Hardenbrook, Long Chen, Anka Lucic, Juan R. Perilla, Eric O. Freed, Peijun Zhang   +11 more
doaj   +2 more sources

How HIV-1 Uses the Metabolite Inositol Hexakisphosphate to Build Its Capsid [PDF]

Viruses
The HIV-1 capsid is one of virology’s most iconic structures, yet how it assembles has long remained elusive. Remarkably, the capsid is made from just a single protein, CA, which forms a lattice of ~250 hexamers and exactly 12 pentamers.
Leo C. James
doaj   +2 more sources

Identification of myo‐inositol hexakisphosphate (IP6) as a β‐secretase 1 (BACE1) inhibitory molecule in rice grain extract and digest

FEBS Open Bio, 2014
Alzheimer’s disease (AD) is widely considered to be caused by amyloid-β peptide (Aβ) accumulation in the brain. Aβ is excised from amyloid-β precursor protein through sequential cleavage by β-secretase 1 (BACE1) and γ-secretase.
Masayuki Taniguchi
exaly   +3 more sources

A Structural Perspective of the Role of IP6 in Immature and Mature Retroviral Assembly

Viruses, 2021
The small cellular molecule inositol hexakisphosphate (IP6) has been known for ~20 years to promote the in vitro assembly of HIV-1 into immature virus-like particles.
Martin Obr, Florian K. M. Schur, Robert A. Dick   +2 more
doaj   +1 more source