Phytic Acid: Properties and Potential Applications in Dentistry
Frontiers in Materials, 2021 Inositol hexaphosphate (IP6) is the most abundant inositol phosphate in nature and an essential molecule for different biological functions. IP6 has a unique structure granting it distinctive properties; a high negative charge density provides IP6 with ...
Mohannad Nassar +8 more
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Phytic acid effect on periodontal ligament fibroblast: An in-vitro study.
PLoS ONE, 2023 ObjectivesThis study evaluated phytic acid (IP6) effect on the viability, alkaline phosphatase (ALP) activity and calcium release of human periodontal ligament (HPDL) cells in optimal (OGL) and elevated glucose level (EGL) in cell culture media.Materials
Smriti Aryal A C +5 more
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Antimicrobial Activity of Phytic Acid: An Emerging Agent in Endodontics
Frontiers in Cellular and Infection Microbiology, 2021 BackgroundPhytic acid (IP6) is a promising and emerging agent, and because of its unique structure and distinctive properties, it lends itself to several applications in dentistry. Recently, IP6 was proposed as a potential chelating agent in endodontics.
Rania Nassar +8 more
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Application of Inositol Hexaphosphate and Inositol in Dental Medicine: An Overview
Biomolecules, 2023 Phosphorylated inositol hexaphosphate (IP6) is a naturally occurring carbohydrate, and its parent compound, myoinositol (Ins), is abundantly present in plants, particularly in certain high-fiber diets, but also in mammalian cells, where they regulate ...
Ana Druzijanic +5 more
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Resin-Based Cement Applied to Enamel and Dentin Pre-Treated with Phytic Acid: An In Vitro Study
Applied Sciences, 2021 Phytic acid (IP6) has the ability to etch tooth structure due to its acidity and chelating properties. This study aimed to evaluate the micro-tensile bond strength (μTBS) of resin-based cement to enamel and dentin using manufacturer-provided etchants ...
Mohannad Nassar +5 more
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Structural insight into host plasma membrane association and assembly of HIV-1 matrix protein
Scientific Reports, 2021 Oligomerization of Pr55Gag is a critical step of the late stage of the HIV life cycle. It has been known that the binding of IP6, an abundant endogenous cyclitol molecule at the MA domain, has been linked to the oligomerization of Pr55Gag.
Halilibrahim Ciftci +26 more
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Anti-angiogenic activity of inositol hexaphosphate (IP6) [PDF]
Carcinogenesis, 2004 A significant anticancer activity of the naturally occurring carbohydrate inositol hexaphosphate (IP(6)) has been reported against numerous cancer models. Since tumors require angiogenesis for growth and metastasis, we hypothesize that IP(6) reduces tumor growth by inhibiting angiogenesis.
Ivana, Vucenik +5 more
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Food & Nutrition Research, 2023 Background: Short bowel syndrome (SBS) has high morbidity and mortality rates, and promoting intestinal adaptation of the residual intestine is a critical treatment.
Weipeng Wang +8 more
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Inositol hexakisphosphate inhibits osteoclastogenesis on RAW 264.7 cells and human primary osteoclasts. [PDF]
PLoS ONE, 2012 BackgroundInoxitol hexakisphosphate (IP6) has been found to have an important role in biomineralization and a direct effect inhibiting mineralization of osteoblasts in vitro without impairing extracellular matrix production and expression of alkaline ...
María del Mar Arriero +3 more
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A novel method for the purification of inositol phosphates from biological samples reveals that no phytate is present in human plasma or urine [PDF]
Open Biology, 2015 Inositol phosphates are a large and diverse family of signalling molecules. While genetic studies have discovered important functions for them, the biochemistry behind these roles is often not fully characterized.
Miranda S. C. Wilson +4 more
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