New insights into the biological role of mammalian ADARs; the RNA editing proteins [PDF]
, 2015 The ADAR proteins deaminate adenosine to inosine in double-stranded RNA which is one of the most abundant modifications present in mammalian RNA.
Arieti, Fabiana +4 more
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Deceptive beauty of non-natural structures. [PDF]
Protein SciAbstract Structures of proteins and multiprotein complexes are considered landmark achievements. However, in many cases, mutant proteins are used for structural work. Even when wild type proteins are used, crystallization or complex formation for cryoEM is performed in highly nonphysiological conditions.
Gurevich VV, Gurevich EV.
europepmc +2 more sources
Influence of pH on the cytotoxic activity of inositol hexakisphosphate (IP6) in prostate cancer
Frontiers in Oncology, 2011 Objectives: In the present study, we investigated whether the pH of IP6 could influence its anti-tumoral activity in vitro. Methods: PC-3 cells were exposed to IP6 at pH 5, pH 7 and pH 12 and we evaluated the metabolic activity (WST-1 assay), cell ...
Blandine eBetton +7 more
doaj +1 more source
Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases
Molecules, 2020 In mammals, a family of three inositol hexakisphosphate kinases (IP6Ks) synthesizes the inositol pyrophosphate 5-IP7 from IP6. Genetic deletion of Ip6k1 protects mice from high fat diet induced obesity, insulin resistance and fatty liver. IP6K1 generated
Sandip Mukherjee +2 more
doaj +1 more source
Antimicrobial Activity of Phytic Acid, Citric Acid, and EDTA with and without Propolis against Enterococcus Faecalis and Candida Albicans [PDF]
Journal of Dental Materials and Techniques, 2022 Introduction: This study aimed to investigate the antimicrobial efficacy of chelation agents on Enterococcus faecalis (E. faecalis) and Candida albicans (C. albicans) when used alone or in combination with propolis.
Merve Yeniçeri Özata +4 more
doaj +1 more source
Rice bran phytic acid (IP6) induces growth inhibition, cell cycle arrest and apoptosis on human colorectal adenocarcinoma cells [PDF]
, 2010 Phytic acid (inositol hexaphosphate or IP6) is one of the bioactive compound that is present in cereals, nuts and legumes. IP6 is a naturally occurring polyphosphorylated carbohydrate, recognized to posses various significant health benefits including ...
Ismail, Norsharina +5 more
core +1 more source
Identification of a major IP5 kinase in Cryptococcus neoformans confirms that PP-IP5/IP7, not IP6, is essential for virulence [PDF]
, 2016 Fungal inositol polyphosphate (IP) kinases catalyse phosphorylation of IP3 to inositol pyrophosphate, PP-IP5/IP7, which is essential for virulence of Cryptococcus neoformans.
Desmarini, D +5 more
core +2 more sources
Open Biology, 2015 Here are comments on the recent paper on the determination of inositol hexaphosphate (IP 6 ) in human plasma and on its efficacy.
openaire +3 more sources
Modulation of transforming growth factor beta2 (TGF-beta2) by inositol hexaphosphate in colon carcinogenesis in rats Modulação do fator transformador de crescimento beta2 (TGFbeta2) pelo inositol hexafosfato na carcinogênese colônica em ratos
Acta Cirúrgica Brasileira, 2006 PURPOSE: To evaluate modulation in the expression of Transforming growth factor beta2 (TGF-beta2) in short-term colon carcinogenesis. METHODS: 64 male rats was used, comprising 4 groups of 16 animals each: group 1 received Inositol hexaphosphate (IP6 ...
Guido Marks +7 more
doaj +1 more source
PLoS Pathogens, 2020 Inositol hexakisphosphate (IP6) potently stimulates HIV-1 particle assembly in vitro and infectious particle production in vivo. However, knockout cells lacking inositol-pentakisphosphate 2-kinase (IPPK-KO), the enzyme that produces IP6 by ...
Clifton L Ricana +3 more
doaj +1 more source