Inositol hexakisphosphate inhibits osteoclastogenesis on RAW 264.7 cells and human primary osteoclasts. [PDF]
PLoS ONE, 2012 BackgroundInoxitol hexakisphosphate (IP6) has been found to have an important role in biomineralization and a direct effect inhibiting mineralization of osteoblasts in vitro without impairing extracellular matrix production and expression of alkaline ...
María del Mar Arriero +3 more
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Anti-angiogenic activity of inositol hexaphosphate (IP6) [PDF]
Carcinogenesis, 2004 A significant anticancer activity of the naturally occurring carbohydrate inositol hexaphosphate (IP(6)) has been reported against numerous cancer models. Since tumors require angiogenesis for growth and metastasis, we hypothesize that IP(6) reduces tumor growth by inhibiting angiogenesis.
Ivana, Vucenik +5 more
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Structure of native HIV-1 cores and their interactions with IP6 and CypA [PDF]
Science Advances, 2021 High-resolution cryoET structures of native HIV-1 capsid in complex with IP6 and CypA are enabled by viral membrane perforation.
Ni, Tao +12 more
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Binding of Inositol Hexakisphosphate (IP6) to Ku but Not to DNA-PKcs [PDF]
Journal of Biological Chemistry, 2002 The nonhomologous DNA end joining (NHEJ) pathway is responsible for repairing a major fraction of double strand DNA breaks in somatic cells of all multicellular eukaryotes. As an indispensable protein in the NHEJ pathway, Ku has been hypothesized to be the first protein to bind at the DNA ends generated at a double strand break being repaired by this ...
Yunmei, Ma, Michael R, Lieber
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A novel method for the purification of inositol phosphates from biological samples reveals that no phytate is present in human plasma or urine [PDF]
Open Biology, 2015 Inositol phosphates are a large and diverse family of signalling molecules. While genetic studies have discovered important functions for them, the biochemistry behind these roles is often not fully characterized.
Miranda S. C. Wilson +4 more
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Modulation of transforming growth factor beta2 (TGF-beta2) by inositol hexaphosphate in colon carcinogenesis in rats Modulação do fator transformador de crescimento beta2 (TGFbeta2) pelo inositol hexafosfato na carcinogênese colônica em ratos
Acta Cirúrgica Brasileira, 2006 PURPOSE: To evaluate modulation in the expression of Transforming growth factor beta2 (TGF-beta2) in short-term colon carcinogenesis. METHODS: 64 male rats was used, comprising 4 groups of 16 animals each: group 1 received Inositol hexaphosphate (IP6 ...
Guido Marks +7 more
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Antimicrobial Activity of Phytic Acid, Citric Acid, and EDTA with and without Propolis against Enterococcus Faecalis and Candida Albicans [PDF]
Journal of Dental Materials and Techniques, 2022 Introduction: This study aimed to investigate the antimicrobial efficacy of chelation agents on Enterococcus faecalis (E. faecalis) and Candida albicans (C. albicans) when used alone or in combination with propolis.
Merve Yeniçeri Özata +4 more
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PLoS Pathogens, 2020 Inositol hexakisphosphate (IP6) potently stimulates HIV-1 particle assembly in vitro and infectious particle production in vivo. However, knockout cells lacking inositol-pentakisphosphate 2-kinase (IPPK-KO), the enzyme that produces IP6 by ...
Clifton L Ricana +3 more
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Targeting the Inositol Pyrophosphate Biosynthetic Enzymes in Metabolic Diseases
Molecules, 2020 In mammals, a family of three inositol hexakisphosphate kinases (IP6Ks) synthesizes the inositol pyrophosphate 5-IP7 from IP6. Genetic deletion of Ip6k1 protects mice from high fat diet induced obesity, insulin resistance and fatty liver. IP6K1 generated
Sandip Mukherjee +2 more
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Open Biology, 2015 Here are comments on the recent paper on the determination of inositol hexaphosphate (IP 6 ) in human plasma and on its efficacy.
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