Rice EARLY SENESCENCE 2, encoding an inositol polyphosphate kinase, is involved in leaf senescence [PDF]
BMC Plant Biology, 2020 Background Early leaf senescence influences yield and yield quality by affecting plant growth and development. A series of leaf senescence-associated molecular mechanisms have been reported in rice.
Shenglong Yang +13 more
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The Vip1 inositol polyphosphate kinase family regulates polarized growth and modulates the microtubule cytoskeleton in fungi. [PDF]
PLoS Genetics, 2014 Microtubules (MTs) are pivotal for numerous eukaryotic processes ranging from cellular morphogenesis, chromosome segregation to intracellular transport. Execution of these tasks requires intricate regulation of MT dynamics.
Jennifer Pöhlmann +11 more
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OsIPK2 Acts as an Organ-Specific Modulator of Rice Trichome Development by Coordinating Cuticular Wax Metabolism and Transcriptional Regulation [PDF]
PlantsTrichomes are specialized epidermal structures that play pivotal roles in plant defense against biotic and abiotic stresses. Inositol polyphosphate kinase 2 (IPK2) is a key enzyme in inositol phosphate metabolism with diverse functions in eukaryotic ...
Yao Chen +8 more
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From Obscurity to Prominence: IPMK’s Expanding Role in Cellular Signaling, Physiology, and Disease [PDF]
BiomoleculesOnce a protein of relative obscurity, inositol polyphosphate multikinase (IPMK) emerged as a versatile and indispensable enzyme in cellular biology. With dual inositol and lipid kinase activities, IPMK generates pivotal signaling molecules such as InsP4 (
Subrata H. Mishra +3 more
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Affinity-Based Interactome Mapping of Inositol Pyrophosphates Reveals 4/6-PP-InsP<sub>5</sub>-Binding Proteins in Plants. [PDF]
Adv Sci (Weinh)ABSTRACT Inositol pyrophosphates (PP‐InsPs) are central regulators of eukaryotic signaling events. While certain PP‐InsP isomers have been conclusively linked to the regulation of phosphate homeostasis through interaction with SPX domain‐containing proteins in plants, the functions of the recently discovered isomer 4/6‐PP‐InsP5 remain largely unknown ...
Ritter K +10 more
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Frontiers in Plant Science, 2018 Soybean is one of the leading oilseed crop in the world and is showing a remarkable surge in its utilization in formulating animal feeds and supplements.
Mansi Punjabi +5 more
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The yeast AMP-activated protein kinase Snf1 phosphorylates the inositol polyphosphate kinase Kcs1 [PDF]
Journal of Biological ChemistryStuart J Decker +2 more
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mBio, 2023 Inositol pyrophosphate 1,5-IP8 is a signaling molecule that regulates phosphate and polyphosphate homeostasis in the fission yeast Schizosaccharomyces pombe. 1,5-IP8 levels are dictated by a balance between the Asp1 kinase domain that converts 5-IP7 to 1,
Ana M. Sanchez +4 more
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mBio, 2022 Inositol pyrophosphates (IPPs) are signaling molecules that regulate cellular phosphate homeostasis in diverse eukaryal taxa. In fission yeast, mutations that increase 1,5-IP8 derepress the PHO regulon while mutations that ablate IP8 synthesis are PHO ...
Bradley Benjamin +5 more
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A late endosome signaling hub that couples PI3Kα and WNT/β-catenin signaling in breast cancer
Molecular & Cellular Oncology, 2021 AKT is the central phosphoinositide 3-kinase (PI3K) signaling effector, however, PIK3CA (p110α subunit of PI3Kα)-mutant estrogen receptor-positive (ER+) breast cancers exhibit minimal AKT activation and the downstream signaling is poorly characterized ...
Samuel J. Rodgers +3 more
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