Results 11 to 20 of about 5,183 (131)

Loss of PI3k activity of inositol polyphosphate multikinase impairs PDK1-mediated AKT activation, cell migration, and intestinal homeostasis

iScience, 2023
Summary: Protein kinase B (AKT) is essential for cell survival, proliferation, and migration and has been associated with several diseases. Here, we demonstrate that inositol polyphosphate multikinase (IPMK’s) lipid kinase property drives AKT activation ...
Luke Reilly, Evan R. Semenza, George Koshkaryan, Subrata Mishra, Sujan Chatterjee, Efrat Abramson, Pamela Mishra, Yoshitasu Sei, Stephen A. Wank, Mark Donowitz, Solomon H. Snyder, Prasun Guha   +11 more
doaj   +1 more source

Inositol Pyrophosphate-Controlled Kinetochore Architecture and Mitotic Entry in S. pombe

Journal of Fungi, 2022
Inositol pyrophosphates (IPPs) comprise a specific class of signaling molecules that regulate central biological processes in eukaryotes. The conserved Vip1/PPIP5K family controls intracellular IP8 levels, the highest phosphorylated form of IPPs present ...
Natascha Andrea Kuenzel, Abel R. Alcázar-Román, Adolfo Saiardi, Simon M. Bartsch, Sarune Daunaraviciute, Dorothea Fiedler, Ursula Fleig   +6 more
doaj   +1 more source

Structures of Fission Yeast Inositol Pyrophosphate Kinase Asp1 in Ligand-Free, Substrate-Bound, and Product-Bound States

mBio, 2022
Expression of the fission yeast Schizosaccharomyces pombe phosphate regulon is sensitive to the intracellular level of the inositol pyrophosphate signaling molecule 1,5-IP8.
Bradley Benjamin, Yehuda Goldgur, Nikolaus Jork, Henning J. Jessen, Beate Schwer, Stewart Shuman   +5 more
doaj   +1 more source

Study on the Function of the Inositol Polyphosphate Kinases Kcs1 and Vip1 of Candida albicans in Energy Metabolism

Frontiers in Microbiology, 2020
In Saccharomyces cerevisiae, inositol polyphosphate kinase KCS1 but not VIP1 knockout is of great significance for maintaining cell viability, promoting glycolysis metabolism, and inducing mitochondrial damage.
Xueling Peng, Qilin Yu, Yingzheng Liu, Tianyu Ma, Mingchun Li   +4 more
doaj   +1 more source

Multiple Inositol Polyphosphate Phosphatase Compartmentalization Separates Inositol Phosphate Metabolism from Inositol Lipid Signaling

Biomolecules, 2023
Multiple inositol polyphosphate phosphatase (MINPP1) is an enigmatic enzyme that is responsible for the metabolism of inositol hexakisphosphate (InsP6) and inositol 1,3,4,5,6 pentakisphosphate (Ins(1,3,4,5,6)P5 in mammalian cells, despite being ...
Jia Yu, Barbara Leibiger, Shao-Nian Yang, Stephen B. Shears, Ingo B. Leibiger, Per-Olof Berggren, Christopher J. Barker   +6 more
doaj   +1 more source

Characterisation of a soil MINPP phytase with remarkable long-term stability and activity from Acinetobacter sp.

PLoS ONE, 2022
Phylogenetic analysis, homology modelling and biochemical methods have been employed to characterize a phytase from a Gram-negative soil bacterium. Acinetobacter sp.
Gregory D Rix, Colleen Sprigg, Hayley Whitfield, Andrew M Hemmings, Jonathan D Todd, Charles A Brearley   +5 more
doaj   +1 more source

Fungal Inositol Pyrophosphate IP₇ Is Crucial for Metabolic Adaptation to the Host Environment and Pathogenicity

mBio, 2015
Inositol pyrophosphates (PP-IPs) comprising inositol, phosphate, and pyrophosphate (PP) are essential for multiple functions in eukaryotes. Their role in fungal pathogens has never been addressed.
Sophie Lev, Cecilia Li, Desmarini Desmarini, Adolfo Saiardi, Nicole L. Fewings, Stephen D. Schibeci, Raghwa Sharma, Tania C. Sorrell, Julianne T. Djordjevic   +8 more
doaj   +1 more source

The wavy Mutation Maps to the Inositol 1,4,5-Trisphosphate 3-Kinase 2 (IP3K2) Gene of Drosophila and Interacts with IP3R to Affect Wing Development

G3: Genes, Genomes, Genetics, 2016
Inositol 1,4,5-trisphosphate (IP3) regulates a host of biological processes from egg activation to cell death. When IP3-specific receptors (IP3Rs) bind to IP3, they release calcium from the ER into the cytoplasm, triggering a variety of cell type- and ...
Derek M. Dean, Luana S. Maroja, Sarah Cottrill, Brent E. Bomkamp, Kathleen A. Westervelt, David L. Deitcher   +5 more
doaj   +1 more source

Fungal Kinases With a Sweet Tooth: Pleiotropic Roles of Their Phosphorylated Inositol Sugar Products in the Pathogenicity of Cryptococcus neoformans Present Novel Drug Targeting Opportunities

Frontiers in Cellular and Infection Microbiology, 2019
Invasive fungal pathogens cause more than 300 million serious human infections and 1.6 million deaths per year. A clearer understanding of the mechanisms by which these fungi cause disease is needed to identify novel targets for urgently needed therapies.
Sophie Lev, Sophie Lev, Sophie Lev, Cecilia Li, Cecilia Li, Desmarini Desmarini, Desmarini Desmarini, Desmarini Desmarini, Tania C. Sorrell, Tania C. Sorrell, Tania C. Sorrell, Adolfo Saiardi, Julianne T. Djordjevic, Julianne T. Djordjevic, Julianne T. Djordjevic   +14 more
doaj   +1 more source

Alteration of the N6-methyladenosine methylation landscape in a mouse model of polycystic ovary syndrome

Journal of Ovarian Research, 2023
Objective To explore the N6-methyladenosine (m6A) methylation abnormality of mRNAs and its potential roles in the mouse model of polycystic ovary syndrome (PCOS).
Lingxiao Zou, Waixing Li, Dabao Xu, Shujuan Zhu, Bin Jiang   +4 more
doaj   +1 more source