Results 51 to 60 of about 5,183 (131)
How does type 2 diabetes modify the risk of Alzheimer's disease?
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract Type 2 diabetes (T2D) and Alzheimer's disease (AD) are both increasing exponentially worldwide. T2D has also been identified as one of 14 modifiable risk factors for dementia, but the mechanism is unknown. T2D could promote dementia via vascular or AD neuropathological changes, and mechanistic hypotheses include central insulin resistance and ...
G. T. Sutherland +7 more
wiley +1 more source
Phytic Acid and Inorganic Phosphate Composition in Soybean Lines with Independent IPK1 Mutations
The Plant Genome, 2015 Soybean seeds contain a large amount of P, which is stored as phytic acid (PA). Phytic acid is indigestible by nonruminant livestock and considered an antinutritional factor in soybean meal.
Jennifer A. Vincent +3 more
doaj +1 more source
Cancer Communications, 2023 Background Proteins containing the Jumonji C (JmjC) domain participated in tumorigenesis and cancer progression. However, the mechanisms underlying this effect are still poorly understood.
Wei Liu +18 more
doaj +1 more source
Histone Modifications in Cardiovascular Disease: Mechanisms and Therapeutic Opportunities
MedComm, Volume 7, Issue 5, May 2026.This graphical abstract summarizes how classical and emerging histone posttranslational modifications (PTMs), together with their chromatin regulators (writers, erasers, and readers), govern major pathobiological programs in cardiovascular disease.
Yu Zheng +8 more
wiley +1 more source
Signaling through non-membrane nuclear phosphoinositide binding proteins in human health and disease
Journal of Lipid Research, 2019 Phosphoinositide membrane signaling is critical for normal physiology, playing well-known roles in diverse human pathologies. The basic mechanisms governing phosphoinositide signaling within the nucleus, however, have remained deeply enigmatic owing to ...
Jamal M. Bryant, Raymond D. Blind
doaj +1 more source
Gap Analysis of Metabolic Conversions of Off‐Flavors and Antinutrients in Plant‐Based Substrates
Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.ABSTRACT To drastically reduce the carbon footprint of the food production chain, a major shift towards alternatives to conventional meat and dairy products is required. The use of plant‐based proteins is a promising route, but it also comes with challenges: Plant‐based proteins often contain antinutritional factors and off‐flavors, which can ...
Robin I. Kuijpers +16 more
wiley +1 more source
Aquaculture, Fish and Fisheries, Volume 6, Issue 2, April 2026.ABSTRACT Plant‐based proteins, such as soybean meal (SBM), have shown promising results in cultured species but also present challenges due to their nutrient composition and inherent antinutritional factors. This study investigated how the replacement of solvent‐extracted SBM with low oligosaccharide soybean meal (LSBM) or enzyme‐treated soybean meal ...
Jamison L. Semla +7 more
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang +18 more
wiley +1 more source
TaPHL7 Transcription Factor Regulates Utilisation of Nitrogen and Phosphorus in Wheat
Plant Biotechnology Journal, Volume 24, Issue 4, Page 2522-2537, April 2026.ABSTRACT Macronutrients nitrogen and phosphorus are essential for plant growth and development, thus being crucial for the productivity of crops. However, the molecular mechanism regulating the utilisation of nitrogen and phosphorus remains elusive. Here, we show that the wheat (Triticum aestivum L.) transcription factor PHOSPHATE STARVATION RESPONSE ...
Huali Wang +13 more
wiley +1 more source
Immune involvement in neuropsychiatric disorders: Insights from single‐cell transcriptomic studies
Psychiatry and Clinical Neurosciences, Volume 80, Issue 4, Page 241-249, April 2026.Neuropsychiatric disorders pose profound challenges to both research and treatment, largely due to their clinical heterogeneity and the limited understanding of their underlying biological mechanisms. While bulk RNA sequencing (bulk RNA‐seq) has been widely used to study gene expression, it cannot resolve cell‐type‐specific signals or detect rare ...
Tsutomu Takeda +4 more
wiley +1 more source