Results 61 to 70 of about 5,183 (131)

Deletion of Aurora kinase A prevents the development of polycystic kidney disease in mice

Nature Communications
Aurora Kinase A (AURKA) promotes cell proliferation and is overexpressed in different types of polycystic kidney disease (PKD). To understand AURKA’s role in regulating renal cyst development we conditionally deleted the gene in mouse models of Autosomal
Ming Shen Tham, Denny L. Cottle, Allara K. Zylberberg, Kieran M. Short, Lynelle K. Jones, Perkin Chan, Sarah E. Conduit, Jennifer M. Dyson, Christina A. Mitchell, Ian M. Smyth   +9 more
doaj   +1 more source

Genetic suppressor screen identifies Tgp1 (glycerophosphocholine transporter), Kcs1 (IP6 kinase), and Plc1 (phospholipase C) as determinants of inositol pyrophosphate toxicosis in fission yeast

mBio
The inositol pyrophosphate signaling molecule 1,5-IP8 is an agonist of RNA 3'-processing and transcription termination in fission yeast that regulates the expression of phosphate acquisition genes pho1, pho84, and tgp1.
Lauren Bednor, Ana M. Sanchez, Angad Garg, Stewart Shuman, Beate Schwer   +4 more
doaj   +1 more source

INPP4B promotes cell survival via SGK3 activation in NPM1-mutated leukemia

Journal of Experimental & Clinical Cancer Research, 2018
Background Acute myeloid leukemia (AML) with mutated nucleophosmin (NPM1) has been recognized as a distinct leukemia entity in the 2016 World Health Organization (WHO) classification.
Hongjun Jin, Liyuan Yang, Lu Wang, Zailin Yang, Qian Zhan, Yao Tao, Qin Zou, Yuting Tang, Jingrong Xian, Shuaishuai Zhang, Yipei Jing, Ling Zhang   +11 more
doaj   +1 more source

P-Rex1 limits the agonist-induced internalization of GPCRs independently of its Rac-GEF activity

Cell Reports
Summary: The guanine-nucleotide exchange factor (GEF) P-Rex1 mediates G protein-coupled receptor (GPCR) signaling by activating the small GTPase Rac. We show here that P-Rex1 also controls GPCR trafficking.
Martin J. Baker, Elizabeth Hampson, Priota Islam, Ruben Pelaez Moral, Eve A. Maunders, Kirsti Hornigold, Elpida Tsonou, Angeliki Malliri, David C. Hornigold, Roderick E. Hubbard, Andrew J. Massey, Heidi C.E. Welch   +11 more
doaj   +1 more source

An integrative analysis of PIK3CA mutation, PTEN, and INPP4B expression in terms of trastuzumab efficacy in HER2-positive breast cancer.

PLoS ONE, 2014
The phosphoinositide-3-kinase (PI3K) pathway is commonly deregulated in breast cancer through several mechanisms, including PIK3CA mutation and loss of phosphatase and tensin homolog (PTEN) and inositol polyphosphate 4-phosphatase-II (INPP4B).
Aiko Sueta, Yutaka Yamamoto, Mutsuko Yamamoto-Ibusuki, Mitsuhiro Hayashi, Takashi Takeshita, Satoko Yamamoto, Hirotaka Iwase   +6 more
doaj   +1 more source

Non-redundant roles of the phosphoinositide phosphatases PTEN and PIPP in PI3K/AKT signaling in breast cancer

Communications Biology
Phosphoinositide 3-kinase (PI3K) signaling is hyperactivated in ~70% of breast cancers via mutations in oncogenes including PIK3CA or inactivation/depletion of phosphoinositide (PI)-phosphatases.
Lisa M. Ooms, Daniel T. Ferguson, Samuel J. Rodgers, Karmanpreet K. Sukhija, Emily I. Jones, Mariah P. Csolle, Hon Yan Kelvin Yip, Roger J. Daly, Tony Tiganis, Catriona A. McLean, Antonella Papa, Christina A. Mitchell   +11 more
doaj   +1 more source

Ubiquitin-specific protease 10 determines colorectal cancer outcome by modulating epidermal growth factor signaling via inositol polyphosphate-4-phosphatase type IIB

Oncogenesis
Although there have been advances in understanding colorectal cancer (CRC) pathogenesis, significant gaps still exist, highlighting the need for deeper insights.
Kateryna Kubaichuk, Timo Seitz, Ulrich Bergmann, Virpi Glumoff, Daniela Mennerich, Thomas Kietzmann   +5 more
doaj   +1 more source

SNHG12 Promotes Autophagy by Blocking the mTOR-Primary Cilia-mTOR Loop via Activating the miR-181a-5p/miR-138-5p-INPP5E Axis in Chondrocyte

International Journal of Clinical Practice
Diseases related to cartilage abnormalities pose a serious threat to human health. Normal cartilage contains only one type of cell, chondrocytes. This study aims to investigate the impact of inositol polyphosphate-5-phosphatase E (INPP5E) on chondrocytes
Weijia Feng, Lei Liu, Lin Sha, Zhenkai Wu, Jing Ding   +4 more
doaj   +1 more source

Pharmacological inhibition of host pathways enhances macrophage killing of intracellular bacterial pathogens

Microbiology Spectrum
After ingestion into macrophage phagosomes, some bacterial pathogens such as Mycobacterium tuberculosis (Mtb) evade killing by preventing phagosome acidification and fusion of the phagosome with a lysosome.
Ramesh Rijal, Richard H. Gomer
doaj   +1 more source

Decoding protein-phospholipid interaction networks in cancer: the role of acyl-chain remodeling. [PDF]

RSC Chem Biol
Blume B, Potter G, Schultz C, Emili A.
europepmc   +1 more source