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Phosphorylation of Proteins by Inositol Pyrophosphates
Science, 2004The inositol pyrophosphates IP 7 and IP 8 contain highly energetic pyrophosphate bonds. Although implicated in various biologic functions, their molecular sites of action have not been clarified. Using radiolabeled IP 7
Adolfo Saiardi +2 more
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Understanding Inositol Pyrophosphates
Science's STKE, 2007Inositol pyrophosphates are relatively poorly understood, highly phosphorylated members of the inositol polyphosphate family. Two studies describe related advances in signaling involving inositol pyrophosphates. Mulugu et al . purified an inositol pyrophosphate synthase from yeast, called Vip1. Lee et al
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Inositol pyrophosphates: structure, enzymology and function
Cellular and Molecular Life Sciences, 2009The stereochemistry of the inositol backbone provides a platform on which to generate a vast array of distinct molecular motifs that are used to convey information both in signal transduction and many other critical areas of cell biology. Diphosphoinositol phosphates, or inositol pyrophosphates, are the most recently characterized members of the ...
Christopher John, Barker +3 more
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Photo-releasable derivatives of inositol pyrophosphates
2020The specific non-invasive control of intracellular signaling events requires advanced tools that enter cells by diffusion and are controllable by light. Here, we detail the synthesis and application of membrane-permeant caged inositol pyrophosphates with respect to cell entry and cell distribution.
Hauke, Sebastian +3 more
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Inositol pyrophosphates: between signalling and metabolism
Biochemical Journal, 2013The present review will explore the insights gained into inositol pyrophosphates in the 20 years since their discovery in 1993. These molecules are defined by the presence of the characteristic ‘high energy’ pyrophosphate moiety and can be found ubiquitously in eukaryotic cells. The enzymes that synthesize them are similarly well distributed and can be
Miranda S C, Wilson +2 more
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Influence of Inositol Pyrophosphates on Cellular Energy Dynamics
Science, 2011Inositol pyrophosphates are implicated in coordination of cell proliferation and metabolism.
Zsolt Szijgyarto +2 more
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Inositol Pyrophosphates in Metabolism Control
Science Signaling, 2011Inositol pyrophosphates are implicated in coordination of cell proliferation and metabolism.
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Chemical tools for interrogating inositol pyrophosphate structure and function
Chemical Society Reviews, 2016New chemical and analytical tools have been developed to study the diverse functions of the inositol pyrophosphates, a unique group of densely phosphorylated intracellular metabolites found in a wide variety of eukaryotic organisms.
Alan M Marmelstein +2 more
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Cell Signalling by Inositol Pyrophosphates
2012Inositol serves as a module for the generation of a high level of molecular diversity through the combinatorial attachment and removal of phosphate groups. The array of potential inositol-containing molecules is further expanded by the generation of diphospho inositol polyphosphates, commonly referred as inositol pyrophosphates.
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