Results 31 to 40 of about 19,281 (194)

Increased Plasma Microbial tDR‐1 in At‐Risk Individuals Is Associated With Decreased Conversion to Clinical Rheumatoid Arthritis and Reduces an In Vitro Macrophage Type 1 Interferon Response

Arthritis &Rheumatology, EarlyView.
Objective Microbial small RNAs can regulate human genes. Higher plasma concentrations of microbial transfer RNA (tRNA)‐derived RNA‐1 (tDR‐1) were previously associated with lower rheumatoid arthritis (RA) disease activity. This study examined whether tDR‐1 concentrations differ in anticyclic citrullinated peptide‐3 positive (CCP3+) at‐risk individuals (
Anastasiia Phothisane, Tulsi K. Joishy, Carolina Ramirez‐Becerra, Qiong Wu, Jennifer Seifert, Marie L. Feser, Jill M. Norris, M. Kristen Demoruelle, LauraKay Moss, Kevin D. Deane, V. Michael Holers, Michelle J. Ormseth   +11 more
wiley   +1 more source

A Cytosine‑Bulged (3+1) Hybrid G‑Quadruplex Formed by the Chicken DNA Replication Origin

Chemistry – A European Journal, EarlyView.
The first high‐resolution structure of an OGRE‐derived G‐quadruplex from the chicken β‐globin replication origin reveals an intramolecular three‐layer (3+1) hybrid fold with a cytosine bulge and an unprecedented 5'‐outer‐quartet anti guanine, creating a distinctive surface for molecular recognition.
Yingying You, Monica Ching Suen, Haitao Miao, Yanyan Geng, Rahman Ud Din, Mu Yuan, Qiang Xue, Xiaoting Li, Naining Xu, Zhihong Guo, Hon‐Ming Lam, Kwok‐Wai Lo, Changdong Liu, Guang Zhu   +13 more
wiley   +1 more source

Directly Sunlight‐Chargeable Core‐Shell Azobenzene Fabric via Coaxial Electrospinning with Tunable Personal Thermal Management

ENERGY &ENVIRONMENTAL MATERIALS, EarlyView.
This work presents a leakage‐free, sunlight‐chargeable core‐shell Azo‐based textile that effectively bridges molecular photothermal storage with wearable functionality, offering a robust platform for on‐demand solar‐powered personal thermal management.
Yating Zhang, Liqi Dong, Hua Pan, Mo Zhou, Fei Zhai, Zhiping Ye, Wei Feng   +6 more
wiley   +1 more source

Projecting the benefit of vericiguat in PARADIGM‐HF and DAPA‐HF populations: Insights from the VICTORIA trial

ESC Heart Failure, Volume 12, Issue 2, Page 1479-1484, April 2025.
Abstract Aims The VICTORIA trial demonstrated a significant reduction in the primary composite outcome of heart failure (HF) hospitalization or cardiovascular death with vericiguat relative to placebo in high‐risk HF. This study aimed to contextualize treatment effects of vericiguat in populations with varying risk profiles simulated from the PARADIGM ...
Veraprapas Kittipibul, Robert J. Mentz, Rebecca Young, Javed Butler, Justin A. Ezekowitz, Carolyn S.P. Lam, Piotr Ponikowski, Adriaan Voors, Stefano Corda, Ciaran McMullan, Christopher M. O'Connor, Kevin J. Anstrom, Paul W. Armstrong, for the VICTORIA Study Group   +13 more
wiley   +1 more source

Hemophagocytic lymphohistiocytosis with immunotherapy: brief review and case report

Journal for ImmunoTherapy of Cancer, 2018
Background Hemophagocytic Lymphohistiocytosis (HLH), a rare but potentially fatal syndrome of immune hyperactivation, may be an under-recognized immune-related adverse event (irAE).
Masood Sadaat, Sekwon Jang
doaj   +1 more source

Gut microbiome in pediatric acute pancreatitis and Crohn's disease versus irritable bowel syndrome and healthy controls

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Pediatric acute pancreatitis (AP), Crohn's disease (CD), and irritable bowel syndrome (IBS) are associated with gut dysbiosis, but differences and similarities between conditions are unknown. We hypothesized that gut microbial ecology would differ across these disorders. Methods Stool was collected from 120 subjects (AP [n = 30], CD
Neha R. Santucci, Chinenye R. Dike, Jenny Hellmann, Nicholas J. Ollberding, Qing Duan, Philip Minar, Lee A. Denson, David B. Haslam, Daniel Castillo, Maisam Abu‐El‐Haija   +9 more
wiley   +1 more source

“It Depends on the Situation”: Variability in How Surgical Oncologists Elicit and Integrate Patient Values

Journal of Surgical Oncology, EarlyView.
ABSTRACT Background Understanding what matters most to patients is central to person‐centered care, particularly in surgical oncology, where decisions often involve significant tradeoffs. We explored how surgeons elicit, integrate, document, and support patient values in cancer‐related decision‐making.
Jacquelyn E. F. Speer, Avery C. Bechthold, Olivia Monton, Anna Newcomb, J. Nicholas Odom, Kimberly E. Kopecky   +5 more
wiley   +1 more source

Polycarbonate Vitrimers and Dynamic Co‐Networks From Epoxide/Carbon Dioxide Copolymerization

Macromolecular Rapid Communications, EarlyView.
This work demonstrates how CO2‐derived poly(propylene carbonate) and poly(cyclohexene carbonate) backbones influence vitrimer thermo‐mechanical behavior. By tuning backbone composition, epoxide crosslinker chemistry and blend ratios, the crosslinked materials span a wide property window, from highly extensible to stiff, glassy networks, establishing an
Satej S. Joshi, Sophia Aracri, Mark D. Foster, James M. Eagan   +3 more
wiley   +1 more source

An ambient-temperature storage and stabilization device performs comparably to flash-frozen collection for stool metabolomics in infants

BMC Microbiology, 2021
Background Stool metabolites provide essential insights into the function of the gut microbiome. The current gold standard for storage of stool samples for metabolomics is flash-freezing at − 80 °C which can be inconvenient and expensive.
Sivapriya Ramamoorthy, Shira Levy, Masouma Mohamed, Alaa Abdelghani, Anne M. Evans, Luke A. D. Miller, Lopa Mehta, Sean Moore, Elizaveta Freinkman, Suchitra K. Hourigan   +9 more
doaj   +1 more source

Quantifying Skin Sodium Concentration With Novel Very Rapid Biexponential T2 Relaxometry and Signal Loss Compensation Methodology

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To accurately measure skin tissue sodium concentration (TSC) through development of spin‐3/2 relaxometry methodology that also considers blood sodium. Methods Mxy generation during RF excitation is substantially reduced by very rapid T2f.
Gurparkash Singh, Christian Beaulieu, Rob Stobbe   +2 more
wiley   +1 more source