Results 101 to 110 of about 1,641,408 (306)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Semi-uniform Input-to-state Stability of Infinite-dimensional Systems
, 2022 We introduce the notions of semi-uniform input-to-state stability and its subclass, polynomial input-to-state stability, for infinite-dimensional systems.
Wakaiki, Masashi
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Input-to-State Stability for Bilinear Feedback Systems
SIAM Journal on Control and Optimization22 ...
René Hosfeld +3 more
openaire +3 more sources
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Separation Principles for Input-Output and Integral-Input-to-State Stability
, 2004 We present new characterizations of input-output-to-state stability. This is a notion of detectability formulated in the ISS (input-to-state stability) framework.
E. D. Sontag +3 more
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SICE Journal of Control, Measurement, and System Integration, 2017 This paper tackles the problem of decentralizing interval observers for robust controlling and monitoring a class of nonlinear systems. The observer-based output feedback system considered in this paper is very different from classical systems in that an
Thach Ngoc Dinh, Hiroshi Ito
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Input-To-State Stability For Discrete-Time Nonlinear Systems
, 1999 : In this paper the input-to-state stability (iss) property is studied for discrete-time nonlinear systems. We show that many iss results for continuoustime nonlinear systems in earlier papers (Sontag, 1989; Sontag, 1990; Sontag and Wang, 1996; Jiang ...
Zhong-ping Jiang +2 more
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source