Results 91 to 100 of about 1,641,408 (306)
Input-output-to-state stability
, 1999 This work explores Lyapunov characterizations of the input-output-to-state stability (ioss) property for nonlinear systems. The notion of ioss is a natural generalization of the standard zero-detectability property used in the linear case.
Eduardo D. Sontag +2 more
core
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Lyapunov functions, stability and input-to-state stability subtleties for discrete-time discontinuous systems [PDF]
, 2009 In this note we consider stability analysis of discrete-time discontinuous systems using Lyapunov functions. We demonstrate via simple examples that the classical second method of Lyapunov is precarious for discrete-time discontinuous dynamics.
Lazar, M Mircea +8 more
core +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Input-to-state Stability on Formation Graphs
, 2002 Formation stability is now analyzed under a new prism using input-to-state stability. Formation ISS relates leader input to internal state of the formation and characterizes the way this input a#ects stability performance.
George J. Pappas +5 more
core
An improved decomposition-aggregation strategy for analyzing power systems stability
International Journal of Electrical Power & Energy SystemsThis paper begins by establishing the presence of a feedforward-feedback control structure within power system dynamics. Subsequently, specific nonlinear analysis tools are employed to investigate the inherent properties of subsystems: Kuramoto Coupled ...
Minquan Chen, Wenqing Hao, Deqiang Gan
doaj +1 more source
Cogent Engineering, 2019 This paper investigates the adaptive control design problem for time-delayed bilateral teleoperation systems with dynamic and kinematic uncertainties. The majority of the previous investigations in the field of teleoperation systems have only considered ...
Afshin Javid, Mohammad Ali Nekoui
doaj +1 more source