YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Biosignal Generation and Latent Variable Analysis with Recurrent Generative Adversarial Networks
, 2019 The effectiveness of biosignal generation and data augmentation with biosignal generative models based on generative adversarial networks (GANs), which are a type of deep learning technique, was demonstrated in our previous paper.
Harada, Shota +2 more
core
Signal processing in local neuronal circuits based on activity-dependent noise and competition
, 2009 We study the characteristics of weak signal detection by a recurrent neuronal network with plastic synaptic coupling. It is shown that in the presence of an asynchronous component in synaptic transmission, the network acquires selectivity with respect to
Andersen P. +7 more
core +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Developing student’s accounting competencies using Astin’s I-E-O model: an identification of key educational inputs based on Indonesian student perspectives [PDF]
, 2011 This paper discusses a model for developing Students’ Accounting Competencies (SAC) using Astin’s Input-Environment-Outcome (I-E-O) model. SAC based on AICPA core competency is considered important due to business and environment changes.
Kavanagh, Marie H. +2 more
core
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Unsteady airfoil stall and stall flutter [PDF]
Unsteady airfoil stall characteristics using static data input for predicting stall flutter boundaries of space shuttle ...
Ericsson, L. E., Reding, J. P.
core +1 more source
Toward improved streamflow forecasts: Value of semidistributed modeling [PDF]
, 2001 The focus of this study is to assess the performance improvements of semidistributed applications of the U.S. National Weather Service Sacramento Soil Moisture Accounting model on a watershed using radar-based remotely sensed precipitation data ...
Boyle, DP +5 more
core +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Computer supported estimation of input data for transportation models [PDF]
, 2010 Control and management of transportation systems frequently rely on optimization or simulation methods based on a suitable model. Such a model uses optimization or simulation procedures and correct input data.
Cenek, Petr +2 more
core +1 more source