Results 101 to 110 of about 68,371 (307)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Innovation, skills and performance in the downturn: an analysis of the UK innovation survey 2011

open access: yes, 2014
The link between firms’ innovation performance and economic cycles, especially major downturns such as that of 2008-10, is a matter of great policy significance, but is relatively under-researched at least at the level of micro data on business ...
Frenz, Marion, Lambert, Ray
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Experimental Science Skills of 9th-Grade Students Through Inquiry-Based Learning

open access: yesJournal of Philology and Educational Sciences
The research aimed to enhance the experimental science skills of 9th grade students by implementing inquiry-based learning management. Specifically, the goal is for students to achieve a passing score of at least 70% of the total points on assessments ...
Thitisuda Phimthong   +4 more
doaj   +1 more source

Efektifitas Model Pembelajaran Inkuiri dalam Meningkatkan Kemampuan Berpikir Kritis Siswa pada Mata Pelajaran Pendidikan Kewarganegaraan

open access: yesJurnal Ilmiah Pendidikan Pancasila dan Kewarganegaraan, 2019
This study aims to examine the effectiveness of inquiry learning models in improving students’ critical thinking skills on Pancasila and Citizenship Education subjects. This type of research uses quasi experimental design. The experimental design that is
Mitra Mustaricha, Nur Wahyu Rochmadi
doaj   +1 more source

Sound science : an approach to teaching content, inquiry skills and the nature of science

open access: yes, 2013
As we teach, it is important not only to focus on science concepts and inquiry skills, but also to help children understand that science is a human endeavor to make sense of the world.
Sickel, Aaron J. (R18021)   +2 more
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Development of an Inquiry-Based Worksheet to Practice Cognitive and Science Process on Light Wave Concepts

open access: yesJPFT (Jurnal Pendidikan Fisika dan Teknologi)
This study aims to develop inquiry skills science worksheets to practice cognitive abilities and science process skills. The research used R&D with ADDIE model (Analysis, Design, Development, Implementation, and Evaluation).
Ikmal Sofil Firdaus   +2 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

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